Developmental and/or epileptic encephalopathy with spike-wave activation in sleep
MONDO:0800501A rare epileptic encephalopathy of childhood characterized by seizures, an electroencephalographic (EEG) pattern of electrical status epilepticus in sleep (ESES) and neurocognitive regression in at least 2 domains of development. This syndrome encompasses the previous syndromes epileptic encephalopathy with continuous spike-wave in sleep and atypical childhood epilepsy with centrotemporal spikes (also previously known as pseudo-Lennox syndrome and atypical benign partial epilepsy).
Also known as: CSWS, CSWSS syndrome, DEE-SWAS, EE-SWAS, EESWAS, ESES with language regression, LK syndrome, LKS
16 clinical trials for this condition and its sub-types, 8 tagged with Developmental and/or epileptic encephalopathy with spike-wave activation in sleep itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Developmental and/or epileptic encephalopathy with spike-wave activation in sleep
-
Can a Cannabis-Based drug calm the Brain's nighttime storm in children?
Disease control CompletedThis trial tests whether Epidiolex, a purified form of cannabidiol, can reduce the abnormal brain activity seen in children with electrical status epilepticus of sleep (ESES). ESES causes continuous seizure-like spikes on EEG during sleep, which can affect learning and behavior. …
Phase 1 • Sponsor: Northwell Health • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
-
New hope for kids with rare sleep epilepsy?
Disease control CompletedThis study tested a drug called NBI-827104 in 24 children with a rare epilepsy that causes constant brain spikes during sleep. The drug is a calcium channel blocker given daily for 13 weeks. The main goal was to see if it reduces abnormal brain activity measured by EEG.
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 26, 2026 13:48 UTC
-
Could a magnetic helmet calm Seizure-Like brain waves in sleeping children?
Symptom relief CompletedThis study tested a wearable device that uses magnetic pulses to stimulate the brain in 10 children with a rare epilepsy called CSWS, where abnormal brain activity occurs during sleep. The device was applied for just 10 minutes to the area causing the seizures. Researchers measur…
Sponsor: Children's Mercy Hospital Kansas City • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC