Developmental and epileptic encephalopathy
MONDO:0100620An epilepsy associated with developmental impairment that may be due to either the underlying etiology or the superimposed epileptic activity, or both.
Also known as: DEE, developmental and epileptic encephalopathy, infantile spasm
106 clinical trials for this condition and its sub-types, 29 tagged with Developmental and epileptic encephalopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Developmental and epileptic encephalopathy
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Genetic developmental and epileptic encephalopathy 2 trials · 83 incl. sub-types
105 sub-types
- Dravet syndrome 39 trials
- Lennox-Gastaut syndrome 26 trials · 27 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 2 10 trials
- Developmental and epileptic encephalopathy, 4 6 trials
- Neonatal-onset developmental and epileptic encephalopathy 0 trials · 5 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 11 4 trials
- Developmental and epileptic encephalopathy, 14 3 trials
- Developmental and epileptic encephalopathy, 1 2 trials
- Developmental and epileptic encephalopathy, 17 2 trials
- Developmental and epileptic encephalopathy 114 1 trial
- Developmental and epileptic encephalopathy, 35 1 trial
- Developmental and epileptic encephalopathy, 7 1 trial
- Non-neonatal early infantile epileptic encephalopathy 1 trial
- DNM1-encephalopathy and neurodevelopmental disorder 0 trials Sub-types →
- TMEM63B-related developmental and epileptic encephalopathy with anemia 0 trials
- Developmental and epileptic encephalopathy 100 0 trials
- Developmental and epileptic encephalopathy 101 0 trials
- Developmental and epileptic encephalopathy 102 0 trials
- Developmental and epileptic encephalopathy 103 0 trials
- Developmental and epileptic encephalopathy 104 0 trials
- Developmental and epileptic encephalopathy 105 with hypopituitarism 0 trials
- Developmental and epileptic encephalopathy 106 0 trials
- Developmental and epileptic encephalopathy 107 0 trials
- Developmental and epileptic encephalopathy 108 0 trials
- Developmental and epileptic encephalopathy 109 0 trials
- Developmental and epileptic encephalopathy 110 0 trials
- Developmental and epileptic encephalopathy 111 0 trials
- Developmental and epileptic encephalopathy 112 0 trials
- Developmental and epileptic encephalopathy 113 0 trials
- Developmental and epileptic encephalopathy 115 0 trials
- Developmental and epileptic encephalopathy 116 0 trials
- Developmental and epileptic encephalopathy 118 0 trials
- Developmental and epileptic encephalopathy 119 0 trials
- Developmental and epileptic encephalopathy 120 0 trials
- Developmental and epileptic encephalopathy 121 0 trials
- Developmental and epileptic encephalopathy 6B 0 trials
- Developmental and epileptic encephalopathy 89 0 trials
- Developmental and epileptic encephalopathy 91 0 trials
- Developmental and epileptic encephalopathy 92 0 trials
- Developmental and epileptic encephalopathy 93 0 trials
- Developmental and epileptic encephalopathy 96 0 trials
- Developmental and epileptic encephalopathy 97 0 trials
- Developmental and epileptic encephalopathy 98 0 trials
- Developmental and epileptic encephalopathy 99 0 trials
- Developmental and epileptic encephalopathy, 15 0 trials
- Developmental and epileptic encephalopathy, 18 0 trials
- Developmental and epileptic encephalopathy, 19 0 trials
- Developmental and epileptic encephalopathy, 23 0 trials
- Developmental and epileptic encephalopathy, 27 0 trials
- Developmental and epileptic encephalopathy, 3 0 trials
- Developmental and epileptic encephalopathy, 30 0 trials
- Developmental and epileptic encephalopathy, 36 0 trials
- Developmental and epileptic encephalopathy, 37 0 trials
- Developmental and epileptic encephalopathy, 38 0 trials
- Developmental and epileptic encephalopathy, 40 0 trials
- Developmental and epileptic encephalopathy, 48 0 trials
- Developmental and epileptic encephalopathy, 49 0 trials
- Developmental and epileptic encephalopathy, 5 0 trials
- Developmental and epileptic encephalopathy, 50 0 trials
- Developmental and epileptic encephalopathy, 51 0 trials
- Developmental and epileptic encephalopathy, 52 0 trials
- Developmental and epileptic encephalopathy, 53 0 trials
- Developmental and epileptic encephalopathy, 54 0 trials
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 56 0 trials
- Developmental and epileptic encephalopathy, 57 0 trials
- Developmental and epileptic encephalopathy, 58 0 trials
- Developmental and epileptic encephalopathy, 59 0 trials
- Developmental and epileptic encephalopathy, 60 0 trials
- Developmental and epileptic encephalopathy, 61 0 trials
- Developmental and epileptic encephalopathy, 62 0 trials
- Developmental and epileptic encephalopathy, 63 0 trials
- Developmental and epileptic encephalopathy, 64 0 trials
- Developmental and epileptic encephalopathy, 65 0 trials
- Developmental and epileptic encephalopathy, 66 0 trials
- Developmental and epileptic encephalopathy, 67 0 trials
- Developmental and epileptic encephalopathy, 68 0 trials
- Developmental and epileptic encephalopathy, 69 0 trials
- Developmental and epileptic encephalopathy, 6A 0 trials
- Developmental and epileptic encephalopathy, 70 0 trials
- Developmental and epileptic encephalopathy, 71 0 trials
- Developmental and epileptic encephalopathy, 72 0 trials
- Developmental and epileptic encephalopathy, 73 0 trials
- Developmental and epileptic encephalopathy, 74 0 trials
- Developmental and epileptic encephalopathy, 75 0 trials
- Developmental and epileptic encephalopathy, 76 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 78 0 trials
- Developmental and epileptic encephalopathy, 79 0 trials
- Developmental and epileptic encephalopathy, 8 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Developmental and epileptic encephalopathy, 81 0 trials
- Developmental and epileptic encephalopathy, 82 0 trials
- Developmental and epileptic encephalopathy, 83 0 trials
- Developmental and epileptic encephalopathy, 84 0 trials
- Developmental and epileptic encephalopathy, 85, with or without midline brain defects 0 trials
- Developmental and epileptic encephalopathy, 86 0 trials
- Developmental and epileptic encephalopathy, 87 0 trials
- Developmental and epileptic encephalopathy, 88 0 trials
- Developmental and epileptic encephalopathy, 9 0 trials
- Developmental and epileptic encephalopathy, 90 0 trials
- Hemiplegic migraine-developmental and epileptic encephalopathy spectrum 0 trials
- Microcephaly, seizures, and developmental delay 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Neonatal-onset encephalopathy with rigidity and seizures 0 trials
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Early-infantile DEE 2 trials
3 sub-types
Most studied deeper sub-types
Developmental and epileptic encephalopathy, 13
(3)
Developmental and epileptic encephalopathy, 25
(1)
Developmental and epileptic encephalopathy, 42
(1)
Developmental and epileptic encephalopathy 94
(1)
Developmental and epileptic encephalopathy, 12
(0)
Developmental and epileptic encephalopathy, 16
(0)
Developmental and epileptic encephalopathy, 21
(0)
Developmental and epileptic encephalopathy, 24
(0)
Developmental and epileptic encephalopathy, 26
(0)
Developmental and epileptic encephalopathy, 28
(0)
Developmental and epileptic encephalopathy, 29
(0)
Developmental and epileptic encephalopathy, 31A
(0)
Developmental and epileptic encephalopathy, 31B
(0)
Developmental and epileptic encephalopathy, 32
(0)
Developmental and epileptic encephalopathy, 33
(0)
Developmental and epileptic encephalopathy, 34
(0)
Developmental and epileptic encephalopathy, 39
(0)
Developmental and epileptic encephalopathy, 43
(0)
Developmental and epileptic encephalopathy, 44
(0)
Developmental and epileptic encephalopathy, 45
(0)
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New drug shows promise for Tough-to-Treat seizures in kids
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Gene therapy trial for rare childhood epilepsy halted after just one patient
Disease control Stopped earlyThis trial tested a single dose of CAP-002 gene therapy in children aged 18 months to 8 years with STXBP1 encephalopathy, a rare genetic brain disorder causing seizures and developmental delays. The study aimed to check safety and whether it could reduce seizures and improve skil…
Phase 1/2 • Sponsor: Capsida Biotherapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Epilepsy drug study for kids halted early: what we know
Disease control Stopped earlyThis study looked at the long-term safety of a drug called NBI-827104 in children with a rare epilepsy that causes seizures during sleep. The trial was stopped early and only enrolled 19 children, so the results are limited. The main goal was to see how many children had serious …
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC