Developmental and epileptic encephalopathy 105 with hypopituitarism

MONDO:0031028

A developmental and epileptic encephalopathy characterized by onset of seizures and pituitary insufficiency in the first weeks or months of life with profoundly impaired development that has material basis in homozygous or compound heterozygous mutation in the HID1 gene on chromosome 17q25.

Also known as: DEE105, developmental and epileptic encephalopathy 105 with hypopituitarism

17 clinical trials for this condition and its sub-types, 0 tagged with Developmental and epileptic encephalopathy 105 with hypopituitarism itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Genetic developmental and epileptic encephalopathy (83)

Including sub-types (17) Tagged with Developmental and epileptic encephalopathy 105 with hypopituitarism (0)

Trials to join now! 5 Not yet finished but already full! 6 Completed 5 Terminated 1

New drug shows promise for Tough-to-Treat seizures in kids

Disease control Stopped early

This study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…

Phase 2 • Sponsor: Takeda • Aim: Disease control

Last updated Sep 06, 2026 00:00 UTC

Developmental and epileptic encephalopathy 105 with hypopituitarism

Where it sits in the disease tree

New drug shows promise for Tough-to-Treat seizures in kids