Dedifferentiated chondrosarcoma
MONDO:0005013An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor.
Also known as: Dedifferentiated chondrosarcoma, DDCHS
2788 clinical trials for this condition and its sub-types, 9 tagged with Dedifferentiated chondrosarcoma itself.
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New hope for rare bone cancer? drug shows promise in early trial
Disease control OngoingThis phase 2 trial tested vismodegib, a pill that targets a specific growth pathway, in 45 people with advanced chondrosarcoma (a rare bone cancer). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had to have measurable disease and no m…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Could a cancer immunotherapy drug shrink rare sarcomas?
Disease control OngoingThis phase 2 trial tests the drug atezolizumab in 27 people with chondrosarcoma or clear cell sarcoma that cannot be removed by surgery or has spread. Atezolizumab is an immunotherapy that helps the body's immune system attack cancer cells. The main goal is to see if the drug can…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Could your own tumor cells fight cancer? new trial tests immune cell therapy
Disease control OngoingThis phase 2 trial tests a treatment called LN-145, made from a patient's own immune cells taken from their tumor. These cells are grown in a lab and then given back to the patient to attack the cancer. The study includes people with ovarian cancer, triple-negative breast cancer,…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Could a common bone drug help fight a rare cancer?
Disease control OngoingThis phase 1b trial is testing whether giving zoledronic acid, a drug usually used for bone thinning, before surgery can help people with chondrosarcoma, a rare bone cancer. Seventeen adults with any grade of the disease that can be surgically removed will receive the drug and th…
Phase 1 • Sponsor: Mohammed Milhem • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC