Cystic fibrosis-related diabetes
MONDO:7770003A form of diabetes mellitus unique to individuals with cystic fibrosis (CF), arising primarily from progressive fibrotic destruction of the pancreas leading to insulin deficiency, with additional contributions from insulin resistance. CFRD affects approximately 20% of adolescents and 40-50% of adults with CF. It shares features with both type 1 and type 2 diabetes but is a distinct clinical entity with its own diagnostic criteria and management guidelines.
Also known as: CF-related diabetes, CFRD
55 clinical trials for this condition and its sub-types, 22 tagged with Cystic fibrosis-related diabetes itself.
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Could a common diabetes drug help manage cystic Fibrosis-Related diabetes?
Disease control OngoingThis pilot study tests the safety and feasibility of empagliflozin (Jardiance) in 8 overweight or obese adults with cystic fibrosis-related diabetes (CFRD) who are already on insulin. Participants will receive either the drug or a placebo in a crossover design. The goal is to gat…
Phase 2/3 • Sponsor: University of Minnesota • Aim: Disease control
Last updated Sep 21, 2026 18:00 UTC
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Bionic pancreas could simplify diabetes care for cystic fibrosis patients
Disease control OngoingThis study tests a device called the iLet Bionic Pancreas, which automatically adjusts insulin delivery based on continuous glucose monitor readings, in people with cystic fibrosis-related diabetes. About 150 participants aged 14 and older will either use the bionic pancreas or t…
Phase 3 • Sponsor: Jaeb Center for Health Research • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Smart insulin pump could ease diabetes in cystic fibrosis patients
Disease control OngoingThis study tests whether a hybrid closed-loop system (CamAPS FX) can improve blood sugar control in people aged 16 and older with cystic fibrosis-related diabetes. The system combines an insulin pump, continuous glucose monitor, and smartphone app to automatically adjust insulin.…
Sponsor: University of Cambridge • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Can CF drugs tame diabetes in cystic fibrosis?
Knowledge-focused By invitation onlyThis study looks at whether CFTR modulators (ETI) help control blood sugar in people with cystic fibrosis-related diabetes (CFRD). Researchers will compare 30 adults with CFRD who take ETI to those who cannot take it. The goal is to see if the drug improves how the body handles s…
Sponsor: University of Alabama at Birmingham • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Cystic fibrosis diabetes gene hunt: 1,500 patients sought
Knowledge-focused By invitation onlyThis study aims to find the genes and other factors that explain why some people with cystic fibrosis develop diabetes while others do not. Researchers will analyze DNA from 1,500 people with cystic fibrosis and their parents. The goal is to better understand the causes of cystic…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Can a simple sensor replace finger pricks for kids in the hospital?
Knowledge-focused By invitation onlyThis study looks at whether continuous glucose monitors (CGMs) are practical for youth aged 2 to 26 with high blood sugar during hospital stays. Researchers will compare CGM readings with standard finger-stick tests and ask patients, families, and nurses about their experience us…
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC