Corneal edema

This study tests a single injection of AURN001 in 120 adults with corneal swelling caused by endothelial dysfunction. The goal is to see if it improves vision and reduces corneal thickness compared to a placebo. Participants must already have an artificial lens in the eye and be …

This study tests whether briefly soaking a donor cornea in a solution made from the patient's own blood (PRGF) before transplant surgery can reduce the loss of important cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal swelling will take pa…

This early-stage trial tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or pseudophakic bullous keratopathy. The implant uses a collagen scaffold with human corneal cells to replace damaged tissue. About 15 participants will receive the impla…

This early-stage trial tests the safety of injecting special human cells (EO2002) into the eye to treat corneal swelling. Twelve adults with corneal edema from Fuchs' dystrophy or after cataract surgery will receive multiple injections, with or without Ripasudil eye drops. The ma…

This study looks at how safe and effective DMEK (a type of cornea transplant) is for people who have already had eye surgeries like vitrectomy or glaucoma surgery. Researchers will track serious complications and vision improvement over 12 months in 80 participants. The goal is t…

This early-stage trial tests a new type of corneal graft made from lab-grown human cells. It is for people with mild to moderate corneal damage from conditions like Fuchs' dystrophy or after eye surgery. The goal is to see if the graft is safe and can improve vision. 30 participa…