Congestive heart failure
MONDO:0005009Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.
Also known as: CHF, cardiac failure, congestive, congestive heart disease, failure, congestive heart, heart failure, congestive
792 clinical trials for this condition and its sub-types, 262 tagged with Congestive heart failure itself.
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Sub-types of Congestive heart failure
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Systolic heart failure 292 trials
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Diastolic heart failure 224 trials
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Left ventricular failure 48 trials
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Cor pulmonale 9 trials · 28 incl. sub-types
2 sub-types
- Chronic pulmonary heart disease 3 trials · 18 incl. sub-types Sub-types →
- Acute cor pulmonale 3 trials
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Rheumatic congestive heart failure 0 trials
Most studied deeper sub-types
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Heart failure fluid removal device trial halted early
Disease control Stopped earlyThis study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However,…
Sponsor: Nuwellis, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Heart failure drug showdown: Once-a-Day pill tested against Twice-a-Day standard
Disease control Stopped earlyThis study tested whether a once-daily dose of Torsemide (a water pill) works as well as the standard twice-daily Furosemide in heart failure patients. The goal was to see how much sodium the body gets rid of and if body weight changes. The study was stopped early and included 20…
Phase 1 • Sponsor: Sarfez Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Heart drug tested to help patients escape life support
Disease control Stopped earlyThis study tested a drug called levosimendan to see if it could help people with severe heart failure successfully come off a temporary heart-lung machine (ECLS). The trial planned to include 82 adults who were ready to try weaning off the machine. Half would get the drug and hal…
Phase 3 • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Heart failure hope? kidney nerve procedure tested in tiny study
Disease control Stopped earlyThis study tested a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in people with chronic heart failure. The goal was to see if it is safe and feasible, and whether it could improve symptoms like walking distance and heart stra…
Sponsor: Universität des Saarlandes • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Can bringing palliative care home ease suffering?
Symptom relief Stopped earlyThis study tested whether providing palliative care at home, through a team of doctors, nurses, social workers, and chaplains, could improve symptoms and quality of life for people with advanced cancer, heart failure, or COPD. The plan was to enroll over 1,100 patients, but the t…
Sponsor: University of Southern California • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can a wearable predict heart failure Flare-Ups before they happen?
Knowledge-focused Stopped earlyThis study is testing a wearable monitoring device designed for people with chronic heart failure to use at home. The device collects physiological data daily for five months, and researchers will then compare that data with any heart failure events, like hospitalizations or wors…
Sponsor: Analog Device, Inc. • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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New E-Health system aims to keep tabs on chronic patients remotely
Knowledge-focused Stopped earlyThis pilot study tested an e-health system that uses tele-monitoring, tele-notification, and tele-coaching to help manage adults with at least two chronic conditions like heart failure, COPD, or diabetes. The goal was to see how well the system could detect health problems early.…
Sponsor: Air Liquide Santé International • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:48 UTC