Congenital syphilis
MONDO:0005714A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Also known as: MTCT of syphilis, congenital syphilis, mother-to-child transmission of syphilis
16 clinical trials for this condition and its sub-types, 7 tagged with Congenital syphilis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Congenital syphilis
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Early congenital syphilis 0 trials
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Late congenital syphilis 0 trials
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Could oral antibiotics replace hospital stays for Syphilis-Exposed newborns?
Disease control Recruiting nowThis study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…
Phase 2 • Sponsor: London School of Hygiene and Tropical Medicine • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Five-Minute Finger-Prick test could speed syphilis diagnosis in pregnancy
Diagnosis Recruiting nowThis study tests whether a rapid finger-prick blood test for syphilis and HIV can be used in a prenatal clinic for pregnant people at risk. The test gives results in five minutes, potentially speeding up diagnosis and treatment. Participants will provide feedback on their experie…
Sponsor: McMaster University • Aim: Diagnosis
Last updated Jul 09, 2026 00:00 UTC
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Penicillin shots tested to stop syphilis in pregnancy
Prevention Recruiting nowThis study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…
Phase 2 • Sponsor: University of California, Los Angeles • Aim: Prevention
Last updated Jun 27, 2026 13:00 UTC