Complex regional pain syndrome type 1
MONDO:0011441Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.
Also known as: Algodystrophy, CRPS I, CRPS1, Complex regional pain syndrome I, RND, RSDS, complex regional pain syndrome type 1, reflex neurovascular dystrophy
152 clinical trials for this condition and its sub-types, 31 tagged with Complex regional pain syndrome type 1 itself.
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Could a tiny dose of naltrexone calm CRPS pain? new study aims to find out.
Symptom relief By invitation onlyThis study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…
Phase 4 • Sponsor: Hospital for Special Surgery, New York • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Could a simple questionnaire replace In-Person exams for CRPS?
Knowledge-focused By invitation onlyThis study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…
Sponsor: Hospital for Special Surgery, New York • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Amputation for pain: how long until patients walk again?
Knowledge-focused OngoingThis study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC