Coagulation protein disease
MONDO:0002242Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding.
Also known as: coagulation factor deficiency, coagulation factor deficiency syndrome
275 clinical trials for this condition and its sub-types, 13 tagged with Coagulation protein disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Coagulation protein disease
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Hemophilia 55 trials · 214 incl. sub-types
4 sub-types
- Hemophilia A 178 trials Sub-types →
- Hemophilia B 84 trials · 91 incl. sub-types Sub-types →
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Factor XI deficiency 0 trials Sub-types →
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Von Willebrand disease (hereditary or acquired) 39 trials · 46 incl. sub-types
2 sub-types
- Hereditary von Willebrand disease 18 trials · 29 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
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Acquired coagulation factor deficiency 4 trials · 15 incl. sub-types
6 sub-types
- Acquired hemophilia 2 trials · 7 incl. sub-types Sub-types →
- Acquired von willebrand syndrome 3 trials
- Acquired factor X deficiency 1 trial
- Acquired factor V deficiency 0 trials
- Acquired factor VII deficiency 0 trials
- Acquired factor XIII deficiency 0 trials
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Factor VII deficiency 6 trials
2 sub-types
- Congenital factor VII deficiency 3 trials
- Acquired factor VII deficiency 0 trials
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Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types
1 sub-type
- Familial dysfibrinogenemia 2 trials · 6 incl. sub-types Sub-types →
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Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types
5 sub-types
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Factor X deficiency 2 trials
2 sub-types
- Acquired factor X deficiency 1 trial
- Congenital factor X deficiency 0 trials
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Congenital factor XII deficiency 1 trial
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Hypoplasminogenemia 1 trial
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East Texas bleeding disorder 0 trials
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Tatsumi factor deficiency 0 trials
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Alpha-2-plasmin inhibitor deficiency 0 trials
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Dysplasminogenemia 0 trials
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Factor V amsterdam bleeding disorder 0 trials
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Factor V atlanta bleeding disorder 0 trials
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Factor V deficiency 0 trials
2 sub-types
- Acquired factor V deficiency 0 trials
- Congenital factor V deficiency 0 trials
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Factor XIII deficiency 0 trials
2 sub-types
- Acquired factor XIII deficiency 0 trials
- Congenital factor XIII deficiency 0 trials Sub-types →
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Inherited prekallikrein deficiency 0 trials
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Plasminogen deficiency, type II 0 trials
Most studied deeper sub-types
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New study tracks Real-World impact of hemophilia drug on joint health
Disease control Recruiting nowThis study follows 250 people with hemophilia A who are taking efanesoctocog alfa to prevent bleeding. Researchers want to see how well it protects joints from bleeds over time in everyday life. Participants will be observed for several years to track bleeding rates and treatment…
Phase 4 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New clotting factor offers continued bleeding control for hemophilia a patients
Disease control Recruiting nowThis study gives people with moderate or severe hemophilia A who finished a previous trial continued access to the drug efanesoctocog alfa. The drug is a lab-made clotting factor that helps prevent bleeding episodes. Researchers will monitor safety and how well it controls bleedi…
Phase 3 • Sponsor: Swedish Orphan Biovitrum • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New trial aims to stop deadly bleeding after birth
Disease control Recruiting nowThis study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery will be randomly assigned to receive either factor XIII plus standard care or standard care a…
Phase 4 • Sponsor: Christian Haslinger • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New study tracks joint health in hemophilia a patients on prophylaxis
Disease control Recruiting nowThis study in Taiwan will follow about 100 people with moderate to severe hemophilia A who are already taking efanesoctocog alfa (a clotting factor) as part of their routine care. Researchers will track joint health, bleeding rates, and safety over up to 5 years using medical rec…
Sponsor: Sanofi • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New study tracks clotting risks after major aortic surgery
Knowledge-focused Recruiting nowThis study watches how blood clotting changes in 58 people after complex surgery to repair a thoraco-abdominal aortic aneurysm. Researchers will check for complications like kidney injury, heart problems, and clotting issues before and after surgery. The goal is to better underst…
Sponsor: University of Thessaly • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New study tracks joint replacement success in bleeding disorder patients
Knowledge-focused Recruiting nowThis study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC