Classical glioblastoma
MONDO:0000457A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification.
Also known as: classical glioblastoma, glioblastoma classical subtype
2822 clinical trials for this condition and its sub-types, 3 tagged with Classical glioblastoma itself.
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Engineered immune cells take on recurrent brain tumors in early trial
Disease control OngoingThis early-phase study tests a new treatment for a type of brain cancer (glioblastoma) that has come back after standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The main goal is to check the safet…
Phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New drug combo aims to tackle Hard-to-Treat cancers
Disease control PausedThis study tests a combination of two drugs, neratinib and valproate, in people with advanced solid tumors that have not responded to standard treatments. The first part finds the safest dose, and the second part focuses on cancers with a RAS mutation, like certain colon and panc…
Phase 1/2 • Sponsor: Virginia Commonwealth University • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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Immune cells engineered to hunt two targets in brain cancer
Disease control OngoingThis early-stage trial tests whether specially engineered immune cells are safe and feasible for people with a recurring type of brain cancer called glioblastoma. The cells are designed to recognize and attack two specific proteins found on the cancer cells. The study involves 67…
Phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC