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Chronic liver failure
MONDO:0100193Liver failure that develops slowly and gradually for some time, possibly for years, often as the result of cirrhosis, or malnutrition.
Also known as: ESLD, end stage liver disease, end stage liver disease (decompensated liver disease), end-stage liver disease
133 clinical trials for this condition and its sub-types, 124 tagged with Chronic liver failure itself.
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Liver drug trial halted after just 3 patients
Disease control Stopped earlyThis study tested a drug called VS-01 for people with severe confusion caused by liver disease (overt hepatic encephalopathy). The trial planned to enroll many participants but was stopped early after only 3 people joined. Researchers wanted to see if VS-01 could help patients re…
Phase 2 • Sponsor: Genfit • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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New liver tests aim to better predict outcomes in End-Stage disease
Knowledge-focused Stopped earlyThis study tested whether a new type of liver function test using a substance called cholate could better assess the severity of liver disease in people with end-stage liver disease. The goal was to improve how doctors predict outcomes and guide treatment. The study included 103 …
Phase 2 • Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Liver transplant study aims to predict outcomes by measuring frailty
Knowledge-focused Stopped earlyThis study looked at whether simple tests of frailty—like grip strength, walking speed, and weight loss—can predict how well liver transplant patients do before and after surgery. Researchers planned to follow 300 adults with end-stage liver disease who were waiting for a transpl…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Heart ultrasound showdown: trained generalists vs. experts in liver patients
Knowledge-focused Stopped earlyThis study looked at whether gastroenterologists (liver doctors) who are not heart ultrasound specialists, but received standard training, could measure heart function as accurately as experts in patients with severe cirrhosis and swelling. The goal was to see if simple heart ass…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC