Chronic liver failure

This study looks at whether propranolol, a drug often used for high blood pressure, helps or harms people with advanced cirrhosis (severe liver scarring). The trial will include 466 adults with a MELD score over 9, meaning their liver disease is fairly advanced. Researchers will …

This study tests a device that keeps donor livers cool and oxygenated before transplant, aiming to reduce early liver problems. About 215 first-time liver transplant patients will receive a liver preserved with this method. The goal is to see if it lowers the risk of early graft …

This study compares two methods of preserving livers from deceased donors before transplant: a machine that pumps oxygenated cold fluid through the liver (hypothermic machine perfusion) versus the standard ice-cooled storage. Forty adult liver transplant patients will be randomly…

This study tests the safety of using a patient's own stem cells (taken from fat) to prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during surgery. The goal is to see if this approach red…

This study tests whether a telemedicine program using a smartphone app and a smartwatch can help people with advanced liver disease (decompensated cirrhosis) avoid hospital stays and emergency room visits. About 120 adults with this condition will either receive standard care or …

This study compares two intravenous fluids—human albumin and saline—to see which better resolves acute kidney injury in people with decompensated cirrhosis. About 114 adults with moderate to severe kidney damage will receive either treatment. The goal is to improve kidney functio…

Acute-on-chronic liver failure (ACLF) is a sudden, life-threatening worsening of long-term liver disease that often leads to multiple organ failure. Standard scoring systems may miss key signs of inflammation and organ damage. This study compares two newer scoring models—the CLIF…

This study follows adults waiting for a liver transplant to see how their sleep quality changes from before surgery to six months after. Researchers use questionnaires to measure sleep, anxiety, and other factors. The goal is to understand what influences sleep problems in these …

This study aims to create a score that predicts the risk of infection within 30 days after a liver transplant. Researchers will collect blood samples from 279 liver transplant patients before and after surgery to measure immune markers. The goal is to combine these markers with o…

This study looks at a simple idea: during a liver transplant, the first blood that flows into the new liver may contain harmful substances. By discarding that blood before connecting the liver to the patient's circulation, doctors hope to reduce heart, kidney, and liver problems.…

This large French study will follow 1,810 adults receiving their first liver transplant to see if the way the donor liver is removed affects outcomes. The main focus is on avoiding artery and bile duct complications for three years after transplant. The goal is to identify the be…

This study will analyze data from 3,000 living liver donors and their recipients to create a more accurate prediction model for early graft failure after living donor liver transplantation. Researchers will also test how well existing prediction models work. The goal is to give d…