Chromosome 21 disorder
MONDO:0700124Chromosomal disorder in which chromosome 21 is affected.
138 clinical trials for this condition and its sub-types, 0 tagged with Chromosome 21 disorder itself.
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Sub-types of Chromosome 21 disorder
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Down syndrome 136 trials · 138 incl. sub-types
3 sub-types
- Trisomy 21 9 trials · 10 incl. sub-types Sub-types →
- Translocation Down syndrome 2 trials Sub-types →
- Partial segmental duplication 1 trial
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Monosomy 21 0 trials
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Ring chromosome 21 0 trials
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Tetrasomy 21 0 trials
Most studied deeper sub-types
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Early safety trial of ION269 for Alzheimer's in down syndrome ends after just one participant
Disease control Stopped earlyThis early-stage study tested a drug called ION269 in adults with Down syndrome who also showed signs of Alzheimer's disease. The goal was to check if the drug was safe and tolerable when injected into the spinal fluid. Only one person took part, and the study was stopped early, …
Phase 1 • Sponsor: Ionis Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Down syndrome hyperactivity drug trial stalls after just 3 kids enrolled
Symptom relief Stopped earlyThis study tested the drug guanfacine to see if it could reduce hyperactivity and impulsivity in children aged 6 to 12 with Down syndrome. The plan was to give the drug or a placebo for 8 weeks and measure behavior changes. However, the trial was stopped early after only 3 childr…
Phase 2 • Sponsor: Rachel G. Greenberg, MD, MB, MHS • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC