Chiari malformation type I
MONDO:0007316Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacement of the cerebellar tonsils exceeding 5mm below the foramen magnum with or without syringomyelia. Symptoms vary in onset and severity and include suboccipital headache, neck pain, vertigo, tinnitus, ocular symptoms (diplopia, blurred vision, photofobia, nystagmus), lower cranial nerve signs, cerebellar ataxia, and spasticity. Some affected individuals can be asymptomatic.
Also known as: Arnold-Chiari malformation type 1, Arnold-Chiari malformation type I, Chiari malformation type 1, Chiari malformation type I, Chiari malformation type 1 with syringomyelia, Cm1, Cm1 with syringomyelia
10 clinical trials for this condition and its sub-types, 9 tagged with Chiari malformation type I itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
Swedish survey asks: what shapes daily life with chiari malformation?
Knowledge-focused By invitation onlyResearchers at Karolinska Institutet are surveying adults in Sweden who have Chiari malformation type 1, a condition where part of the brain pushes into the spinal canal. The study asks how these patients rate their health-related quality of life compared with the general Swedish…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
-
MRI study reveals how neck position impacts brain fluid flow
Knowledge-focused By invitation onlyThis study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and pat…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC