Chiari malformation
MONDO:0000115A rare genetic brain malformation characterized by displacement of the brain stem and cerebellum through the foramen magnum. It may result in hydrocephalus.
Also known as: (Arnold) Chiari malformation, Arnold-Chiari malformation, Chiari malformation
14 clinical trials for this condition and its sub-types, 13 tagged with Chiari malformation itself.
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Sub-types of Chiari malformation
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Chiari malformation type I 9 trials
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Chiari malformation type II 2 trials
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Chiari malformation type 3 0 trials
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Chiari malformation type 4 0 trials
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Keyhole surgery in the womb could fix spina bifida with fewer risks
Disease control OngoingThis study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Swedish survey asks: what shapes daily life with chiari malformation?
Knowledge-focused By invitation onlyResearchers at Karolinska Institutet are surveying adults in Sweden who have Chiari malformation type 1, a condition where part of the brain pushes into the spinal canal. The study asks how these patients rate their health-related quality of life compared with the general Swedish…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Neuro-Patch under the microscope: Real-World surgery study launched
Knowledge-focused OngoingThis study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …
Sponsor: Aesculap AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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MRI study reveals how neck position impacts brain fluid flow
Knowledge-focused By invitation onlyThis study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and pat…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC