Chagas cardiomyopathy
MONDO:0005491A disease of the cardiac muscle developed subsequent to the initial protozoan infection by trypanosoma cruzi. After infection, less than 10% develop acute illness such as myocarditis (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced chagas disease include conduction defects (heart block) and cardiomegaly.
Also known as: Trypanosoma cruzi cardiomyopathy, Trypanosoma cruzi caused cardiomyopathy
11 clinical trials for this condition and its sub-types, 3 tagged with Chagas cardiomyopathy itself.
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Can a common heart drug help chagas patients? new trial results
Disease control CompletedThis study tested whether sacubitril/valsartan (Entresto) works better than enalapril for people with heart failure caused by chronic Chagas disease. Over 900 adults with reduced heart function took part. The goal was to see if the drug could reduce heart-related deaths, hospital…
Phase 4 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Can cutting nerves stop deadly heart rhythms in chagas patients?
Disease control CompletedThis pilot study tested a procedure called bilateral sympathectomy, which cuts certain nerves to the heart, in 45 Chagas disease patients with implantable defibrillators (ICDs) who had frequent dangerous heart rhythms. Participants were randomly assigned to receive the nerve-cutt…
Sponsor: University of Sao Paulo General Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC