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CDKL5 disorder
MONDO:0100039A monogenic disease that has material basis in mutation in the CDKL5 gene.
Also known as: CDKL5 Deficiency Disorder, CDKL5 disorder, CDKL5 inherited genetic disease, inherited genetic disease caused by mutation in CDKL5, CDKL5, CDKL5-related disorder
11 clinical trials for this condition and its sub-types, 8 tagged with CDKL5 disorder itself.
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Sub-types of CDKL5 disorder
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Can a daily tablet quiet the seizures of two devastating genetic disorders?
Symptom relief CompletedResearchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …
Phase 2 • Sponsor: Takeda • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Warm baths tested as seizure treatment for rare childhood disorder
Symptom relief CompletedThis study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…
Sponsor: Xuanwu Hospital, Beijing • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Fever's impact on seizures in rare genetic disorder revealed
Knowledge-focused CompletedThis study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…
Sponsor: Xuanwu Hospital, Beijing • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC