Cathepsin a-related arteriopathy-strokes-leukoencephalopathy
MONDO:0035551A rare genetic cerebral small vessel disease characterized by an adult-onset primary microangiopathy with severe atherosclerosis of arterioles and secondary leukoencephalopathy. Patients may present with migraine, transient ischemic attacks, stroke with central facial palsy, cognitive dysfunction with impaired concentration, dementia, depression, movement disorder, vertigo, dysphagia, dysarthria, sicca syndrome, impaired REM sleep, and therapy-resistant hypertension, among others. Brain MRI typically shows a leukoencephalopathy that is disproportionately severe and extensive compared to the clinical disease.
Also known as: CARASAL
10 clinical trials for this condition and its sub-types, 0 tagged with Cathepsin a-related arteriopathy-strokes-leukoencephalopathy itself.
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Massive korean registry to unlock secrets of heart and stroke
Knowledge-focused Recruiting nowThis study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…
Sponsor: Samsung Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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New stroke registry aims to unlock secrets of brain damage
Knowledge-focused Recruiting nowThis study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …
Sponsor: Justin Fraser • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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New microscope gadget aims to give surgeons X-Ray vision during delicate operations
Knowledge-focused Recruiting nowThis study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…
Sponsor: Leica Microsystems (Schweiz) AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Robot takes the joystick for brain surgery – first human test underway
Knowledge-focused Recruiting nowThis early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…
Sponsor: Navigantis Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC