Capillary leak syndrome

MONDO:0001956

A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.

Also known as: AVLS, CLS, Clarkson disease, SCLS, Systemic Capillary Leak Syndrome, acute vascular leak syndrome, capillary hyperpermeability syndrome, capillary leak syndrome

1 clinical trial for this condition and its sub-types, 1 tagged with Capillary leak syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7133) ↑ Capillary disorder (4)

Including sub-types (1) Tagged with Capillary leak syndrome (1)

Completed 1

Tiny blood vessel coating may hold key to fluid management in surgery

Knowledge-focused Completed

This study looked at a thin layer of proteins and sugars that lines blood vessels, called the glycocalyx, in 28 people having heart surgery. The goal was to see if changes in this layer relate to fluid leaking out of blood vessels, which can cause swelling. By measuring glycocaly…

Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused

Last updated Jun 27, 2026 13:06 UTC

Capillary leak syndrome

Where it sits in the disease tree

Tiny blood vessel coating may hold key to fluid management in surgery