Breast adenocarcinoma

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study asks whether a dose-dense chemotherapy combination called CMF (cyclophosphamide, methotrexate, and fluorouracil) can be a practical alternative to the standard AC regimen (doxorubicin and cyclophosphamide) for people aged 70 and older with early-stage breast cancer. Th…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This early-phase trial is testing a modified measles virus (MV-s-NAP) that is injected directly into tumors in people with metastatic breast cancer. The virus is designed to kill cancer cells and also carry an extra protein to boost the immune response. Researchers are monitoring…

This phase 3 trial tests whether a shorter, higher-dose radiation schedule (3 weeks) is as safe and effective as the standard 5-week schedule for women with high-risk breast cancer who have had a mastectomy and immediate implant reconstruction. The study will enroll 506 women and…

This early-stage trial is testing a combination of two chemotherapy drugs (melphalan and BCNU) plus vitamins B12b and C, followed by an infusion of the patient's own stem cells. The goal is to see if this approach is safe for people with metastatic pancreatic or breast cancer, es…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. It tests whether adding a short course of targeted radiation (SBRT) to continued chemotherapy can help eliminate more cancer before surgery. About 96 participants wi…

This study is for people with advanced breast cancer who cannot or choose not to have surgery. Researchers want to see if adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. About 30 participants will receive radiation and be mon…

This phase II trial is testing whether combining two drugs—trastuzumab deruxtecan (Enhertu) and durvalumab—given before surgery can eliminate cancer in people with stage III inflammatory breast cancer that has HER2 protein. The study will enroll 63 participants and measure how ma…

This study tests a hydrogel made from bacterial cellulose and coconut oil monolaurin to prevent severe skin reactions in Filipino women with breast cancer undergoing radiation therapy. About 54 participants will apply either the hydrogel or a placebo cream daily. The goal is to s…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study collects blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. Researchers want to see how the immune system reacts to these treatments. The goal is to learn more, not to test a new the…

This study looks at how aromatase inhibitor therapy changes skin quality and self-esteem in breast cancer survivors. Researchers will use skin imaging and surveys to track changes in 35 women starting this hormone therapy. The goal is to better understand and manage these side ef…

This study follows 2000 people with early-stage, hormone-sensitive breast cancer to see how doctors decide on treatments, especially when using a test called EndoPredict. The goal is to track long-term outcomes like cancer return and survival over 5 to 10 years. No new treatments…

This study looks at how chemotherapy changes certain nerve reflexes that control blood pressure and exercise responses in breast cancer patients. Researchers will compare 24 women who recently finished chemotherapy with healthy volunteers. The goal is to understand these changes …