Brain hypoxia - ischemia

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial tha…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study looks at whether gentle foot massage (reflexology) can improve comfort and vital signs in newborns with brain injury from oxygen loss, who are receiving cooling treatment. About 84 stable newborns will either get standard care or standard care plus foot reflexology. Re…

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…

This study looks at whether being at a moderate altitude (like 4,000 meters) can hurt your ability to remember to do things later, called prospective memory. Fifty healthy adults will take memory tests while breathing low-oxygen air or normal air in a chamber. Researchers also wa…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study looks at whether a protein called neurofilament light chain (NfL) in the blood can help measure brain injury in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by lack of oxygen at birth. Researchers will measure NfL levels at several time point…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …