Bone cancer
MONDO:0002129A primary or metastatic malignant neoplasm affecting the bone or articular cartilage.
Also known as: bone neoplasm, bone tumor, bone tumour, osseous tumor, osseous tumour, bone cancer, cancer of bone, cancer of skeletal element
4613 clinical trials for this condition and its sub-types, 79 tagged with Bone cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Bone cancer
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Bone marrow cancer 2 trials · 1,631 incl. sub-types
1 sub-type
- Myeloproliferative neoplasm 165 trials · 1,630 incl. sub-types Sub-types →
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Bone carcinoma 0 trials · 131 incl. sub-types
7 sub-types
- Metastatic carcinoma in the bone 107 trials
- Paranasal sinus carcinoma 4 trials · 21 incl. sub-types Sub-types →
- Bone squamous cell carcinoma 0 trials · 11 incl. sub-types Sub-types →
- Pituitary adenocarcinoma 3 trials Sub-types →
- Adamantinoma 0 trials Sub-types →
- Growth hormone-producing pituitary gland carcinoma 0 trials
- Osteosarcoma arising in bone Paget disease 0 trials
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Bone sarcoma 41 trials · 108 incl. sub-types
13 sub-types
- Undifferentiated pleomorphic sarcoma 48 trials Sub-types →
- Dedifferentiated chondrosarcoma 9 trials
- Bone giant cell tumor 7 trials · 8 incl. sub-types Sub-types →
- Bone osteosarcoma 8 trials Sub-types →
- Ewing sarcoma of bone 5 trials
- Undifferentiated high grade pleomorphic sarcoma of bone 4 trials
- Clear cell chondrosarcoma 3 trials
- Malignancy in giant cell tumor of bone 1 trial
- Bone angiosarcoma 0 trials
- Bone fibrosarcoma 0 trials
- Bone leiomyosarcoma 0 trials
- Liposarcoma of bone 0 trials
- Periosteal chondrosarcoma 0 trials
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Primary bone lymphoma 1 trial · 92 incl. sub-types
3 sub-types
- Acute biphenotypic leukemia 88 trials · 91 incl. sub-types Sub-types →
- Paranasal sinus lymphoma 0 trials
- Sternum lymphoma 0 trials
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Skull cancer 0 trials · 38 incl. sub-types
6 sub-types
- Paranasal sinus cancer 4 trials · 24 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Skull base chordoma 5 trials Sub-types →
- Pituitary cancer 2 trials · 4 incl. sub-types Sub-types →
- Orbital cancer 0 trials · 2 incl. sub-types Sub-types →
- Malignant jugulotympanic paraganglioma 0 trials
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Bone chondrosarcoma 1 trial · 10 incl. sub-types
3 sub-types
- Dedifferentiated chondrosarcoma 9 trials
- Clear cell chondrosarcoma 3 trials
- Periosteal chondrosarcoma 0 trials
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Cancer affecting bone of limb skeleton 0 trials · 1 incl. sub-types
4 sub-types
- Cancer of long bone of lower limb 0 trials · 1 incl. sub-types Sub-types →
- Cancer of long bone of upper limb 0 trials
- Cancer of short bone of lower limb 0 trials
- Cancer of short bone of upper limb 0 trials
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Adult extraskeletal osteosarcoma 0 trials
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Chest wall bone cancer 0 trials
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Small cell osteogenic sarcoma 0 trials
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Sternum cancer 0 trials
1 sub-type
- Sternum lymphoma 0 trials
Most studied deeper sub-types
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Engineered immune cells take on Hard-to-Treat sarcomas
Disease control Not yet recruitingThis early-stage trial is testing a combination of specially engineered immune cells (CAR T cells) and a vaccine for people with sarcoma that has come back or spread. The goal is to see if the treatment is safe and can help shrink tumors. About 20 participants will receive the th…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Engineered immune cells take on Hard-to-Treat sarcomas
Disease control Not yet recruitingThis trial tests a 4th-generation safety-engineered CAR T cell therapy for people with relapsed or late-stage sarcomas, including osteosarcoma and Ewing sarcoma. Participants receive a single infusion of these immune cells designed to target and attack sarcoma cells. The study ai…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Could a simple blood swap cut transfusions in bone cancer surgery?
Disease control Not yet recruitingThis study tests whether removing some blood during bone cancer surgery and replacing it with fluid (acute normovolemic hemodilution) can reduce the need for donor blood transfusions. The trial will include 420 adults undergoing elective bone cancer surgery. The goal is to see if…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New combo therapy aims to tackle tough bone cancer
Disease control Not yet recruitingThis study looks at whether giving radiation and chemotherapy together before surgery can help control high-risk Ewing sarcoma, a type of bone cancer. Researchers will follow 55 patients to see how well the treatment works and how safe it is. The goal is to improve local tumor co…
Sponsor: Peking University People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New drug combo aims to stall bone sarcoma in phase 2 trial
Disease control Not yet recruitingThis study tests whether combining two drugs, lenvatinib and everolimus, works better than everolimus alone for people with advanced bone sarcoma (osteosarcoma, Ewing sarcoma, or chondrosarcoma) that has progressed after standard treatment. About 94 adults aged 19 to 79 will be r…
Phase 2 • Sponsor: Yonsei University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New hope for rare bone cancer: targeted drugs enter early trial
Disease control Not yet recruitingThis early-phase trial will test two targeted drugs, crizotinib and alectinib, in 10 adults with a rare form of bone cancer that has a specific ALK gene change. Participants must have already tried standard treatments or have no standard options left. The goal is to see if these …
Phase 1/2 • Sponsor: China Medical University Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New combo therapy aims to cut blood transfusions in bone tumor surgery
Disease control Not yet recruitingThis study tests whether giving a combination of intravenous iron, erythropoietin (EPO), and tranexamic acid before bone tumor surgery can improve hemoglobin levels and reduce the need for blood transfusions compared to usual care. The trial enrolls 160 adults with anemia or iron…
Phase 4 • Sponsor: Tang Xiaodong • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Smartwatch exercise plan aims to rebuild fitness in young cancer survivors
Symptom relief Not yet recruitingThis trial tests whether a personalized, smartwatch-supported home exercise program can increase physical activity and improve heart health, mobility, and quality of life in adolescents and young adults who have survived bone or soft tissue sarcoma. Participants wear a fitness tr…
Sponsor: Universität Duisburg-Essen • Aim: Symptom relief
Last updated Jul 29, 2026 00:00 UTC
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Real-Time nerve monitoring during spine surgery could predict bladder and bowel function
Knowledge-focused Not yet recruitingThis trial tests whether monitoring sacral reflexes during surgery can predict nerve function afterward. Patients undergoing sacrectomy for pelvic bone cancer or spinal procedures will have their reflexes tracked in real time. The goal is to help surgeons make decisions and prepa…
Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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New database aims to reduce bone cancer surgery risks
Knowledge-focused Not yet recruitingThis study will collect information from 400 people having surgery for bone cancer. The goal is to track complications like infections or blood clots and understand how to improve care. By analyzing this data, researchers hope to find ways to make surgery safer and recovery faste…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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New study to assess custom prosthetics for bone cancer patients
Knowledge-focused Not yet recruitingThis study looks at how well people do after surgery to remove bone tumors and rebuild the bone with special implants. It includes 100 adults aged 30 to 70 with certain bone cancers or tumors that have spread to bone. The goal is to learn more about how these custom or 3D-printed…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC