Benign recurrent intrahepatic cholestasis

MONDO:0019008

Benign recurrent intrahepatic cholestasis (BRIC) is a hereditary liver disorder characterized by intermittent episodes of intrahepatic cholestasis, generally without progression to chronic liver damage. BRIC is now believed to belong to a clinical spectrum of intrahepatic cholestatic disorders that ranges from the mild intermittent attacks in BRIC to the severe, chronic and progressive cholestasis seen in progressive familial intrahepatic cholestasis (PFIC).

Also known as: BRIC, Bric, Summerskill-Walshe-Tygstrup syndrome, cholestasis, benign recurrent intrahepatic

12 clinical trials for this condition and its sub-types, 2 tagged with Benign recurrent intrahepatic cholestasis itself.

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Where it sits in the disease tree

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Part of

↑ Inborn disorder of bilirubin metabolism (39) ↑ Familial intrahepatic cholestasis (17)

Sub-types of Benign recurrent intrahepatic cholestasis

Benign recurrent intrahepatic cholestasis type 2 0 trials · 4 incl. sub-types
1 sub-type
- Progressive familial intrahepatic cholestasis type 2 4 trials
Benign recurrent intrahepatic cholestasis type 1 0 trials

Including sub-types (12) Tagged with Benign recurrent intrahepatic cholestasis (2)

Not yet finished but already full! 1 Completed 1

Promising long-term results for rare liver disease drug in kids

Disease control Completed

This study looked at the long-term safety and effectiveness of a drug called A4250 (odevixibat) in 116 children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease. The children took the drug for up to 72 weeks. The study measured changes in bile acid …

Phase 3 • Sponsor: Albireo, an Ipsen Company • Aim: Disease control

Last updated Sep 05, 2026 00:00 UTC

Benign recurrent intrahepatic cholestasis

Where it sits in the disease tree

Promising long-term results for rare liver disease drug in kids