Barrett esophagus

This study tests whether vonoprazan, a newer type of acid-suppressing medication, reduces acid reflux in the esophagus better than standard proton pump inhibitors (PPIs) in people with Barrett's esophagus. Participants will first take their usual PPI for a week, then switch to vo…

This pilot study tests whether ursodeoxycholic acid (UDCA), a medication already used for liver and gallbladder conditions, can improve healing of the esophagus after endoscopic treatment for Barrett's esophagus with dysplasia. The study follows about 15 patients who take UDCA du…

This study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…

This study tests whether a fluorescent tracer called WGA-800CW can make precancerous or cancerous cells in Barrett's esophagus glow during endoscopy. The tracer is sprayed onto the esophagus, and special cameras detect the glow. The goal is to find the best dose and see if this m…

Laparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study tests whether sending reminders to primary care doctors before patient visits can increase screening for Barrett's esophagus, a condition that raises the risk of esophageal cancer. Researchers will compare screening rates before and after the reminders in 3,000 adults.…

This study looks at whether sharing genetic risk information with Barrett's esophagus patients can improve their quality of life and reduce cancer worry. Researchers will collect tissue samples and use genetic analysis to create risk profiles. Half of the 266 participants will le…

This study will follow 750 adults in France who undergo endoscopic submucosal dissection (ESD) for early esophageal cancer or precancerous Barrett's esophagus. Researchers will track how well the procedure removes the cancer, how often it comes back, and whether additional treatm…