Bacterial infectious disease with sepsis

This trial tests whether children and teens with uncomplicated bloodstream infections can safely switch from intravenous (IV) antibiotics to oral antibiotics earlier than usual. Half the participants will switch to oral antibiotics as soon as they are stable, within 4 days of sta…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibio…

This study tests whether giving a daily antibiotic (pivmecillinam) to kidney transplant patients at high risk of bloodstream infections can reduce those infections. 150 participants will receive either the antibiotic or a placebo for 5 months after transplant. The goal is to see …

This study will test whether giving an extra antibiotic during a heart valve replacement procedure (TAVI) can lower the chance of bloodstream infection or death within 6 months. About 2,000 patients in Denmark will take part. Half will get the standard antibiotic, and half will g…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

This study tests whether adjusting beta-lactam antibiotics based on blood levels helps critically ill sepsis patients recover faster. 198 adults in the ICU will be randomly assigned to either standard dosing or dosing guided by regular blood tests. The goal is to see if personali…

Researchers are building a web-based simulation platform to model how long blood cultures take from collection to result reporting in sepsis cases. The study involves microbiological laboratories that perform blood culture analysis. The goal is to understand how lab infrastructur…

This study follows adults with multiple myeloma or B-cell lymphoma who receive CAR-T cell therapy, a powerful immune treatment. Researchers track infections that occur in the first year after treatment, looking at how common they are, what causes them, and which factors raise the…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…

This study tests a new rapid diagnostic system that can tell doctors which antibiotic will work against a blood infection in 4-6 hours, instead of the usual 18-24 hours. Researchers want to see if this faster information helps ICU doctors change to a better antibiotic sooner. The…

This observational study will compare blood cultures taken from arterial lines versus standard vein punctures in 1,500 ICU patients. The goal is to see if the arterial method reduces contamination and improves detection of bloodstream infections. Researchers will also check if mo…