Autoimmune pulmonary alveolar proteinosis
MONDO:0012579Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of a lipoproteinaceous substance in the distal air spaces which positively stains with periodic acid-Schiff (PAS).
Also known as: APAP, Pulmonary Alveolar Proteinosis, autoimmune PAP, iPAP, idiopathic PAP, idiopathic pulmonary alveolar proteinosis, PAP, PAP acquired
41 clinical trials for this condition and its sub-types, 6 tagged with Autoimmune pulmonary alveolar proteinosis itself.
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New hope for rare lung disease: investigational drug now available through expanded access
Disease control Expanded accessThis program offers adults with autoimmune pulmonary alveolar proteinosis (aPAP) access to an investigational inhaled medication called molgramostim. aPAP is a rare lung condition where surfactant builds up, making breathing difficult. The drug aims to help the lungs clear this b…
Sponsor: Savara Inc. • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New hope for kids with rare lung condition: inhaled protein therapy in trial
Disease control Recruiting nowThis study tests an inhaled drug called molgramostim in children aged 6 to 18 with autoimmune pulmonary alveolar proteinosis (aPAP), a rare disease where protein builds up in the lungs and makes breathing hard. All 5 participants will take the drug daily via a nebulizer for 12 mo…
Phase 3 • Sponsor: Savara Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Scientists hunt for hidden genes behind pituitary tumors
Knowledge-focused Recruiting nowThis study aims to find new genes that cause pituitary tumors, including those that lead to acromegaly (gigantism) and prolactinomas. Researchers will collect blood and tissue samples from up to 10,000 people with these tumors and their family members. By analyzing DNA, they hope…
Sponsor: Barts & The London NHS Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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New national registry aims to unlock mysteries of rare lung disease
Knowledge-focused Recruiting nowThis study creates a national registry for people with pulmonary alveolar proteinosis (PAP), a rare lung condition. Researchers will collect data and blood samples to improve diagnosis, understand how the disease progresses, and develop better ways to measure its severity. Up to …
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC