Atypical endometrial hyperplasia
MONDO:0006096An endometrial hyperplasia characterized by cytologic and architectural changes which may lead to endometrial carcinoma. Despite the atypical features and possible course, there is debate on whether to consider this a neoplasm. The relationship with endometrial intraepithelial neoplasia is also unclear.
Also known as: atypical hyperplasia of endometrium, atypical hyperplasia of the endometrium, endometrial hyperplasia with atypia
29 clinical trials for this condition and its sub-types, 28 tagged with Atypical endometrial hyperplasia itself.
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Can a Weight-Loss drug and an IUD treat early uterine cancer without surgery?
Disease control Not yet recruitingResearchers are testing whether a combination of semaglutide (Wegovy), a levonorgestrel-releasing intrauterine device (LNG-IUD), and a structured weight loss program can treat endometrial atypical hyperplasia or early-stage, grade 1 endometrioid endometrial cancer in women who wa…
Phase 2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Weight-loss shot plus IUD may help reverse womb cancer without surgery
Disease control Not yet recruitingThis phase 2 trial tests whether adding tirzepatide (a weight-loss injection) to a levonorgestrel intrauterine device (LNG-IUD) can eliminate precancerous or early-stage endometrial cancer in overweight or obese women. About 55 women who want to avoid hysterectomy will receive bo…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Can a Weight-Loss drug boost Fertility-Sparing cancer treatment?
Disease control Not yet recruitingThis trial tests whether adding mazdutide, a weekly injection that helps with weight loss, to a hormonal intrauterine device (IUD) can improve treatment for overweight or obese women with atypical endometrial hyperplasia or early-stage endometrioid endometrial cancer who wish to …
Phase 2 • Sponsor: Tongji Hospital • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Could a common Weight-Loss drug help hormone therapy work better for young women with endometrial cancer?
Disease control Not yet recruitingThis trial tests whether adding orlistat, a weight-loss drug that blocks fat absorption, to standard progestin therapy can improve treatment response in young women (45 or younger) with early-stage endometrial cancer or atypical endometrial hyperplasia who have low progesterone r…
Phase 2 • Sponsor: Peking University People's Hospital • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Can weight-loss drugs and hormones make endometrial cancer surgery safer for obese women?
Disease control Not yet recruitingThis study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…
Phase 4 • Sponsor: Hospital Universitari de Bellvitge • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Weight-Loss drug may slow uterine tumors before surgery
Disease control Not yet recruitingThis study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will receive either tirzepatide or no additional treatment for 4 weeks be…
Phase 2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Could a diabetes shot help beat uterine cancer without surgery?
Disease control Not yet recruitingThis study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy can better treat early-stage uterine cancer or pre-cancer in overweight women. About 30 participants will either get the standard progesterone IUD alone or the IUD plus tirzepatide. The g…
Phase 2 • Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Pap smear upgrade? DNA test could spot hidden uterine cancer
Diagnosis Not yet recruitingThis observational study will test a new molecular test called CISENDO, which looks at DNA methylation in cells from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers wi…
Sponsor: Peking Union Medical College Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:05 UTC
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Could your daily urine predict uterine cancer?
Knowledge-focused Not yet recruitingThis study will ask 50 people aged 35 and older with abnormal uterine bleeding to collect daily urine samples and track their bleeding at home for several months. Researchers will use a home monitor to measure hormone levels and see if certain patterns are linked to uterine cance…
Sponsor: University of British Columbia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC