Astrocytoma (excluding glioblastoma)

This study tested the drug cabozantinib in 19 people with a severe type of brain tumor (grade IV astrocytic tumors) that had come back after initial treatment. The goal was to see if the drug could shrink tumors or slow progression. However, the company stopped the trial early fo…

This study tested a new drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent anaplastic astrocytoma or glioblastoma. The goal was to find the safest dose and see if the combination worked better than temozolomide alone. The…

This phase 2 trial tested the drug tovorafenib (DAY101) in 23 people aged 12 and older with recurrent or progressive solid tumors that have specific genetic changes in the MAPK pathway. The goal was to see how many patients' tumors shrank or disappeared. The study was terminated …

This early-phase trial tested whether the antifungal drug ketoconazole could block a protein called tGLI1 in brain tumors. It included 15 people with breast cancer that spread to the brain or with a type of brain cancer called glioma. The study was terminated early, so we have li…

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…

This study looked at a tiny molecule called microRNA-10b in people with brain tumors called gliomas. Researchers wanted to see if higher levels of this molecule could help predict how the disease might progress or how long patients might live. The study was stopped early, but it …