Aortic valve stenosis
MONDO:0042981Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever.
Also known as: AS, aortic stenosis, rheumatic aortic stenosis, rheumatic aortic valve stenosis, stenosed aortic valve, valvular aortic stenosis
371 clinical trials for this condition and its sub-types, 319 tagged with Aortic valve stenosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Aortic valve stenosis
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Supravalvular aortic stenosis 3 trials
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Childhood aortic valve stenosis 0 trials
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Congenital aortic valve stenosis 0 trials
2 sub-types
- Aortic valve atresia 0 trials
- Aortic valve dysplasia 0 trials
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Subvalvular aortic stenosis 0 trials
1 sub-type
- Discrete subaortic stenosis 0 trials
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Can a less invasive valve replacement tame a failing aortic valve?
Disease control Stopped earlyThis study is a patient registry that collects information on people with severe aortic stenosis or aortic regurgitation who are treated with the Trilogy heart valve system, a device implanted via a catheter (TAVI) to replace the aortic valve without open-heart surgery. The goal …
Sponsor: JenaValve Technology, Inc. • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Could a diabetes pill protect your heart valve?
Disease control Stopped earlyThis study tests whether evogliptin, a drug originally for diabetes, can slow calcium buildup in the aortic valve of people with mild-to-moderate aortic stenosis. About 580 adults will take either the drug or a placebo daily for two years. The main goal is to see if the drug redu…
Phase 2/3 • Sponsor: REDNVIA Co., Ltd. • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Heart valve study halted early: which blood thinner is safer?
Disease control Stopped earlyThis study compared two antiplatelet drug regimens after transcatheter aortic valve implantation (TAVI) for aortic stenosis. One group received ticagrelor alone, the other received aspirin plus clopidogrel. The goal was to see which caused fewer serious complications like bleedin…
Phase 3 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could ditching heparin during heart valve repair cut bleeding risks?
Disease control Stopped earlyThis trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…
Phase 4 • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Experimental heart slicing procedure tested on one patient
Disease control Stopped earlyThis early study tested a new procedure called SESAME that uses a wire threaded through blood vessels to slice away excess heart muscle in people with hypertrophic cardiomyopathy. Only one adult participated before the study was terminated. The goal was to see if the technique co…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Heart valve scoring device trial halted after just one patient
Disease control Stopped earlyThis study tested a device called Leaflex™ Performer, which is threaded through a blood vessel to the heart to score and loosen calcium buildup on stiff aortic valves. It was designed for people with severe aortic stenosis who cannot have standard valve surgery or replacement. Ho…
Sponsor: Pi-cardia • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Massive german study compares new and old heart valve procedures
Knowledge-focused Stopped earlyThis study was a large registry that planned to follow 180,000 patients in Germany with aortic valve problems (leaky or narrowed valves). The goal was to compare newer, less invasive treatments like TAVI with standard open-heart surgery to see which works best and for whom. Resea…
Sponsor: German Aortic Valve Registry • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC