Aortic arch defects
MONDO:0015236Congenital abnormalities of the aortic arch result from aberrant development of one or more components of the embyronic pharangeal arch system. Any component of this system can regress or persist abnormally, resulting in an extensive array of aortic arch anomalies. Clinically, they are classified by those that cause (or are likely to cause) physiolgogical abnormalities and those that do not. Physiologic abnormalities include tracheobronchial compression, esophageeal compression, and abnormal blood flow patteren.
29 clinical trials for this condition and its sub-types, 1 tagged with Aortic arch defects itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Aortic arch defects
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Takayasu arteritis 27 trials
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Kommerell diverticulum 0 trials
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Neuhauser anomaly 0 trials
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Dysphagia lusoria 0 trials
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Encircling double aortic arch 0 trials
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Persistent fifth aortic arch 0 trials
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Right aortic arch 0 trials
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New drug aims to tame rare artery disease
Disease control OngoingThis phase 3 trial tests whether upadacitinib (Rinvoq) can help people with Takayasu arteritis, a rare disease that inflames large arteries. About 56 adults who have had a recent relapse despite steroids will receive either upadacitinib or a placebo, along with a steroid taper. T…
Phase 3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New heart solution tested in Kids' surgery: could it offer better protection?
Disease control PausedThis study compares two solutions, Custodiol and Custodiol-N, used to protect the heart during surgery for children with congenital heart defects. About 100 children will receive one of the two solutions while on a heart-lung machine. The goal is to see which one is safer and bet…
Phase 2 • Sponsor: Dr. F. Köhler Chemie GmbH • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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New Light-Based sensors could spot hidden heart defects in newborns
Knowledge-focused By invitation onlyThis study tests whether combining standard monitoring tools with new light-based sensors can better detect a dangerous narrowing of the aorta in newborns. Infants under one month old with suspected aortic arch obstruction will be monitored using resonance Raman spectroscopy, pul…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC