Antiphospholipid syndrome

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This phase 2 trial tested whether the drug telitacicept can reduce levels of harmful antibodies in 20 people with antiphospholipid syndrome, a condition that raises the risk of blood clots. Participants received either telitacicept plus standard care or standard care alone for 48…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

Researchers at Yale University are studying whether certain gut bacteria are linked to the autoantibodies that drive antiphospholipid syndrome, an autoimmune disorder that causes dangerous blood clots. The study follows 16 adults, including patients with the syndrome, people who …

This study looks at whether two additional lab tests can better predict the risk of blood clots in people with antiphospholipid syndrome (APS), an autoimmune condition that can cause clots and pregnancy complications. Researchers will measure specific antibodies and thrombin gene…

This study uses special MRI scans to see if the white matter in the brain gets worse over time in women who have obstetric antiphospholipid syndrome, a condition that can cause pregnancy loss. Researchers will compare brain images from 40 women who were part of an earlier study. …

This study looked at 100 pregnant women to determine normal ranges for a blood test called dRVVT, which checks for clotting problems. The goal is to better identify antiphospholipid syndrome, a condition that raises the risk of blood clots and pregnancy complications. By establis…

This study examined whether measuring a protein called ADAMTS13 in early pregnancy can help predict preeclampsia in women with antiphospholipid antibody syndrome (APS). Researchers analyzed stored blood samples from 513 women in the NOH-APS cohort who became pregnant after their …

This study followed over 1,500 women who had pregnancy losses and were tested for antiphospholipid syndrome (APS) and other clotting disorders. Researchers compared cancer rates among women with APS, those with other clotting gene changes, and those with no clotting issues. The g…

This study followed 513 women with antiphospholipid syndrome starting a new pregnancy. Researchers measured two blood markers (PGF and sFlt1) before and after the first low-molecular-weight heparin injections. The goal was to see if changes in these markers could predict serious …

This study created a registry to collect medical information from 868 people with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to gather data on these conditions, not to test a new treatment. Participants were adults diagnosed with APS …

This study looked at how common major psychiatric disorders are in women with antiphospholipid syndrome (a blood clotting disorder) and similar pregnancy loss histories. Researchers compared three groups of women about 10 years after their initial diagnosis. The goal was to under…

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…