Anterior segment dysgenesis
MONDO:0019503A spectrum of developmental anomalies that affect the development of the anterior segment of the eyeball resulting from abnormalities of neural crest migration and differentiation during embryologic development (Axenfeld-Rieger syndrome, Peters anomaly, posterior keratoconus, and iridoschisis).
Also known as: ASGD, ASMD, ASOD, anterior segment mesenchymal dysgenesis, anterior segment ocular dysgenesis, familial ocular anterior segment mesenchymal dysgenesis
21 clinical trials for this condition and its sub-types, 2 tagged with Anterior segment dysgenesis itself.
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Sub-types of Anterior segment dysgenesis
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Congenital primary aphakia 17 trials
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Iridogoniodysgenesis 0 trials · 2 incl. sub-types
7 sub-types
- FOXC1-related anterior segment dysgenesis 0 trials · 1 incl. sub-types Sub-types →
- Congenital microcoria 1 trial
- Rieger anomaly 0 trials Sub-types →
- Aniridia-cerebellar ataxia-intellectual disability syndrome 0 trials
- Bilateral acute depigmentation of the iris 0 trials
- Chromosome 6pter-p24 deletion syndrome 0 trials
- Congenital ectropion uveae 0 trials
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Peters anomaly 1 trial
2 sub-types
- Peters anomaly-cataract syndrome 0 trials
- Von Hippel anomaly 0 trials
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Anterior segment dysgenesis 1 1 trial
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Anterior segment dysgenesis 6 1 trial
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Anterior segment dysgenesis 7 0 trials
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Anterior segment dysgenesis 8 0 trials
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Isolated iridoschisis 0 trials
Most studied deeper sub-types
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Can newer cataract lenses keep vision clear for years?
Disease control CompletedThis study follows adults who had cataract surgery with Clareon Vivity or PanOptix intraocular lenses, which are designed to restore vision at multiple distances. Researchers will track visual acuity and watch for complications like lens dislocation or retinal detachment over sev…
Sponsor: Alcon Research • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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New lens aims to correct both cataracts and astigmatism in one go
Disease control CompletedThis study is checking the long-term safety and performance of a special lens called the Clareon Toric IOL, which is implanted during cataract surgery to also correct astigmatism. About 129 people with cataracts and astigmatism are taking part. The main goal is to see how well th…
Sponsor: Alcon Research • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Eye surgery showdown: does tunnel direction affect lens fixation success?
Disease control CompletedThis study compares two ways of creating scleral tunnels during flanged intrascleral intraocular lens (IOL) fixation surgery, a procedure used when the eye's natural lens support is missing or damaged. Researchers are testing whether making the tunnel horizontally (parallel to th…
Sponsor: Yuzuncu Yil University • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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PanOptix lens safety confirmed years after surgery
Disease control CompletedThis study looked at the long-term safety and performance of AcrySof PanOptix trifocal lenses in 211 people who had them implanted in both eyes 3 to 5 years earlier. Researchers checked vision and recorded any eye problems or device issues. The goal was to make sure these lenses …
Sponsor: Alcon Research • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New lens implant aims to sharpen vision at all distances
Symptom relief CompletedThis study tested a newer trifocal lens implant (Clareon PanOptix Pro) against an older one (Clareon PanOptix) in 71 adults having cataract surgery in both eyes. Each person got one of each lens, so their eyes could be compared directly. The goal was to see if the newer lens prov…
Sponsor: Alcon Research • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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New lens vs. old lens: which gives sharper sight after cataract surgery?
Symptom relief CompletedThis study tested two different trifocal lens implants used during cataract surgery to see which one gives better vision. 87 people who needed cataract surgery in both eyes received one type of lens in each eye. The main goal was to measure how clearly they could see letters on a…
Sponsor: Alcon Research • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Cataract lens study checks vision quality after surgery
Knowledge-focused CompletedThis study looked at how well the Clareon Vivity and Vivity Toric intraocular lenses work in people who already had cataract surgery. Researchers measured vision at different distances in 155 participants. The goal was to confirm the lenses perform as expected and support their u…
Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Blood test uncovers rare diseases in patients with mysterious enlarged spleen
Knowledge-focused CompletedThis study looked for two rare genetic diseases, Gaucher disease and acid sphingomyelinase deficiency (ASMD), in 122 adults with an unexplained enlarged spleen or who had their spleen removed for unknown reasons. Researchers used a simple blood spot test to check enzyme activity …
Sponsor: Fundación Española de Hematología y Hemoterapía • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC