Anaplastic oligoastrocytoma
MONDO:0016703An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity.
Also known as: WHO grade III mixed glioma, aMOA, anaplastic mixed glioma, anaplastic oligoastrocytoma, AOAST
2840 clinical trials for this condition and its sub-types, 12 tagged with Anaplastic oligoastrocytoma itself.
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Experimental drug ruxolitinib joins standard therapy in brain cancer battle
Disease control CompletedThis early-phase study tested whether adding the experimental drug ruxolitinib to standard radiation and chemotherapy (temozolomide) is safe for people with newly diagnosed high-grade gliomas or glioblastoma. Ruxolitinib targets proteins that help cancer cells grow. The study enr…
Phase 1 • Sponsor: Case Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New chemo cocktail shows promise for rare brain tumor patients
Disease control CompletedThis study tested a combination of two chemotherapy drugs (BCNU and TMZ) given before radiation therapy in 53 people newly diagnosed with a rare type of brain cancer called anaplastic oligodendroglioma. The goal was to see how well the drugs shrank tumors and to learn more about …
Phase 2 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Brain tumor chemo delivered by pump shows promise in tiny safety trial
Disease control CompletedThis early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered conti…
Phase 1 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC