Anal canal carcinoma in situ
MONDO:0004707A carcinoma in situ involving a anal canal.
Also known as: anal canal in situ carcinoma, carcinoma in situ of anal canal, stage 0 anal canal cancer, stage 0 anal canal cancer aJCC v6, stage 0 anal canal cancer aJCC v6 and v7, stage 0 anal canal cancer aJCC v7, stage 0 anal canal carcinoma, stage 0 anal canal carcinoma aJCC v6 and v7
2909 clinical trials for this condition and its sub-types, 12 tagged with Anal canal carcinoma in situ itself.
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Could a probiotic fight anal cancer in HIV patients?
Disease control Recruiting nowThis study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…
Phase 2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Turmeric suppositories could replace surgery for anal precancer
Disease control Recruiting nowThis early-stage trial tests whether curcumin (the active ingredient in turmeric) can reverse high-grade anal precancerous lesions in people living with HIV. Participants insert curcumin capsules into the anus daily for 14 days. The main goal is to find the safest dose, not yet t…
Phase 1 • Sponsor: Lisa Flowers • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Could a common HIV drug be repurposed as an anal cream?
Disease control Recruiting nowThis early-stage study tests whether a cream made from two HIV drugs (lopinavir/ritonavir) can be safely placed inside the anus to treat high-grade anal growths (AIN 2/3) in people living with HIV. About 21 participants will receive the cream for a few months and be followed for …
Phase 1 • Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Nerve block may ease radiation pain for anal cancer patients
Symptom relief Recruiting nowThis study tests a nerve block called ganglion impar neurolysis to see if it can reduce pain caused by radiation therapy for anal cancer. Five adults with localized anal cancer who are getting chemotherapy and radiation will receive the nerve block. Researchers will track pain sc…
Sponsor: Emory University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Scientists seek tissue samples to unlock HIV and cancer mysteries
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC