Altitude sickness

This trial studies people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers want to see if spending one week at sea level and then returning to high altitude changes pressure in the lung's blood vessels. They will measure heart and lun…

This trial studies people with pulmonary arterial hypertension, a condition where high blood pressure strains the lungs, who live permanently above 2600 meters. Researchers test whether spending one week at sea level and then returning to altitude changes how far participants can…

This study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

Researchers are testing whether a one-week stay at sea level improves walking ability and blood oxygen in people with pulmonary arterial hypertension who live permanently above 2600 meters. The study compares these patients with healthy controls from the same altitude, measuring …

This study looks at whether a one-week stay at sea level helps people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers will measure lung function, blood oxygen, and sleep quality before, during, and after the descent and re-ascent. Th…

Researchers are studying healthy adults who live above 2600 meters to see how their lungs respond when they descend to sea level for a week and then return to their usual altitude. The trial measures pulmonary resistance, which is how hard the heart must work to pump blood throug…

Researchers are studying what happens when people who live permanently above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. They will measure lung blood pressure and other heart and lung functions in healthy adults and in patients with pulmonary arterial hyper…

This trial asks whether a one-week stay at sea level can lower blood pressure in the lungs of people with pulmonary arterial hypertension who live permanently above 2600 meters. Researchers will compare heart and lung measurements taken at high altitude with those taken after sev…

This study follows healthy adults who live above 2600 meters as they descend to sea level for one week and then return to their usual altitude. Researchers measure lung function, blood oxygen, and sleep before, during, and after the trip. The goal is to see how the lungs respond …

This study looks at what happens when people with pulmonary arterial hypertension, a condition that raises pressure in the lung's blood vessels, travel from their homes above 2600 meters down to sea level for a week, and then return. Researchers will measure heart rate variabilit…

This study looks at what happens when people who live above 2600 meters, in places like Quito, spend a week at sea level and then return to altitude. Researchers will measure sleep quality, oxygen levels during the night, and breathing patterns in healthy adults and in people wit…

Researchers are studying healthy adults who live permanently above 2600 meters, like in Quito, Ecuador. They will travel by bus to sea level for one week, then return to high altitude. The study measures heart rate variability, blood oxygen levels, and sleep patterns during the d…

Researchers are studying what happens when people with pulmonary arterial hypertension who live above 2600 meters spend a week at sea level. The trial compares their sleep, blood oxygen, and breathing during sleep at altitude and after seven days at sea level. It includes both pa…

This study looks at what happens when healthy people who live above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. Researchers will measure walking distance, oxygen levels, and other health markers before and after the descent. The goal is to understand how th…

This study looks at what happens when healthy people who live above 2600 meters spend a week at sea level and then return to their high-altitude home. Researchers measure walking distance, oxygen levels, and heart rate before and after the re-ascent. The goal is to understand how…

This study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…

This study looks at whether being at a moderate altitude (like 4,000 meters) can hurt your ability to remember to do things later, called prospective memory. Fifty healthy adults will take memory tests while breathing low-oxygen air or normal air in a chamber. Researchers also wa…

This study looks at whether a medicine called iloprost can be given to people with severe frostbite (grades 3-4) in remote, high-altitude places like Mount Everest. The goal is to see if it's safe and practical to start treatment before reaching a hospital. Ten adults with severe…