Alport syndrome

MONDO:0018965

A rare renal disease characterized by glomerular nephropathy with hematuria progressing to end-stage renal disease (ESRD), frequently associated with sensorineural deafness, and occasionally with ocular anomalies.

Also known as: hereditary nephritis, Alport deafness-nephropathy, Alport syndrome, Alport's syndrome

20 clinical trials for this condition and its sub-types, 17 tagged with Alport syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7158) ↑ Hereditary nephritis (152)

Sub-types of Alport syndrome

X-linked Alport syndrome 3 trials
Autosomal recessive Alport syndrome 2 trials
Alport syndrome 3b, autosomal recessive 0 trials
Autosomal dominant Alport syndrome 0 trials
Digenic Alport syndrome 0 trials

Including sub-types (20) Tagged with Alport syndrome (17)

Trials to join now! 9 Not yet finished but already full! 3 Completed 7 Terminated 1

Experimental kidney drug for alport syndrome falls short in early trial

Disease control Stopped early

This phase 2 trial tested a weekly injection of lademirsen in 43 adults with Alport syndrome, a genetic condition that damages kidneys. The goal was to see if the drug could slow the decline in kidney function. The study was terminated early, so the results are limited and it's u…

Phase 2 • Sponsor: Genzyme, a Sanofi Company • Aim: Disease control

Last updated Jun 26, 2026 16:08 UTC

Alport syndrome

Where it sits in the disease tree

Experimental kidney drug for alport syndrome falls short in early trial