Allergic asthma

This study tests whether a six-month course of dupilumab can calm the immune system enough for patients with severe olive pollen asthma to then benefit from standard allergy immunotherapy. Researchers will use advanced molecular profiling to understand how the treatment restores …

This 5-year study is looking at how well a year-round allergy treatment (MATA trees or MATA grass) works for children and adults with pollen allergies, including hay fever and mild asthma. Researchers want to see if the treatment is as effective in kids as it is in adults. About …

This Phase 3 trial tests dexpramipexole, an oral tablet, as an add-on treatment for people with eosinophilic asthma that is not well controlled. About 600 participants aged 12 and older will receive either the drug or a placebo for 24 weeks. The study measures improvements in lun…

This study tests a new injection called LP-003 in 6 teenagers aged 12 to 18 who have allergies like hay fever, asthma, or eczema. The main goal is to check if the drug is safe and how the body processes it. This is an early-stage trial, so it focuses on safety and drug levels rat…

This pilot study tests whether tezepelumab, a drug already approved for severe asthma, can also reduce nasal symptoms caused by hayfever in people who have both allergic asthma and allergic rhinitis. Nineteen participants will receive monthly injections of tezepelumab for 12 mont…

This study explores why some people develop airway inflammation after breathing wood smoke while others do not. Researchers will expose healthy adults and those with mild allergic asthma to controlled wood smoke particles and measure immune cell changes in the lungs. They will al…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study aims to improve how asthma is diagnosed and treated by developing new tests and targeted therapies. Researchers will enroll 60 adults with asthma to test a special oil additive and measure lung function and quality of life. The goal is to create better tools for managi…

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also improve physical activity and exercise tolerance in people with severe asthma. Researchers will track daily steps and activity levels in 62 adults over six months. The goal is to see i…

This study looks at how certain immune cells, called memory Th2 cells, that stay in the lungs may trigger allergic asthma attacks when a person breathes in allergens like cat or dust mite dander. Researchers will take samples from the airways of 37 people with mild to moderate al…

This study looks at how breathing in low levels of ozone—similar to what you might encounter on a typical day in Chapel Hill—affects lung function and airway inflammation in adults with mild asthma. Researchers will compare ozone exposure to filtered air in 18 participants. The g…