Alcoholic liver cirrhosis

Researchers are testing whether a single injection of a patient's own bone marrow stem cells, delivered into the liver's main artery, can help people with alcoholic cirrhosis live longer without needing a liver transplant. The trial enrolls about 200 adults with moderate to sever…

Researchers are testing whether adding TAK-242 and G-CSF to standard care is safe and more effective than standard care alone for people with severe alcoholic hepatitis and acute-on-chronic liver failure (ACLF). TAK-242 aims to block an immune system overreaction, while G-CSF enc…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can safely slow or stop liver scarring (cirrhosis) compared to a placebo. About 256 adults with compensated cirrhosis will take the drug or placebo for 2 years. The main goal is to measure changes in liver stiffn…

This study tests whether a supplement called SAMe can improve liver function and reduce deaths in people with alcoholic cirrhosis. About 196 adults with mild to moderate cirrhosis will take SAMe or a placebo daily for 24 months. Researchers will measure liver health, gut function…

This study tests whether taking capsules of processed donor stool (fecal transplant) can help people with liver cirrhosis avoid serious infections and hospital stays. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo an…

Researchers are following 100 people with alcoholic liver cirrhosis who previously received Cellgram-LC, a stem cell therapy made from their own bone marrow. Over five years, the team checks by phone for serious side effects such as new cancers, immune reactions, or the need for …

This study is looking at whether detailed heart imaging can help predict heart problems in people with liver cirrhosis who undergo a procedure called TIPSS, which creates a shunt to relieve pressure in the liver. Participants will have heart MRIs and echocardiograms before, short…

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study looks at how two different proteins—whey and egg white—affect blood ammonia levels in people with advanced liver disease caused by alcohol. High ammonia can harm brain function. Fifty patients will try both proteins on separate days, and their blood and thinking skills…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver disease, and healthy non-drinkers. The goal is to create a biorepository that researchers can use to study biomarkers and improve understanding of the disease. P…

This study looks at how well people with alcohol-related liver cirrhosis understand health information and how confident they feel managing their condition. Researchers will survey 200 participants to measure these factors and track liver complications over time. The goal is to l…