AIDS dementia complex
MONDO:0020689A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Also known as: AIDS dementia, AIDS dementia complex, ADC, ADC - Acquired immune deficiency syndrome dementia complex, AIDS - Acquired immune deficiency syndrome dementia complex, AIDS Dementia, AIDS Dementia Complex, AIDS Encephalopathies
7 clinical trials for this condition and its sub-types, 6 tagged with AIDS dementia complex itself.
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Walking and socializing may protect brain health in HIV+ latinos
Disease control CompletedThis study tested a program called HOLA (Happy Older Latinos are Active) in 30 Latino adults aged 50+ living with HIV. The program included one-on-one sessions with a community health worker, group walks three times a week, and planning pleasant activities. The goal was to see if…
Sponsor: University of Miami • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Brain training boosts thinking in older HIV patients
Symptom relief CompletedThis study tested whether 20 hours of computer-based executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. About 119 participants were split into a training group and a no-contact control g…
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Could an HIV belly-fat drug also sharpen memory?
Symptom relief CompletedThis study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…
Phase 2 • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC