Agammaglobulinemia

MONDO:0015977

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes.

Also known as: agammaglobulinemia, Gammaglobulin Deficiency, Immunoglobulin Deficiency, antibody Deficiency

85 clinical trials for this condition and its sub-types, 16 tagged with Agammaglobulinemia itself.

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Where it sits in the disease tree

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Part of

↑ B cell deficiency (86)

Sub-types of Agammaglobulinemia

Syndromic agammaglobulinemia 7 trials · 37 incl. sub-types
3 sub-types
- Common variable immunodeficiency 29 trials · 31 incl. sub-types Sub-types →
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome 0 trials
- Transient hypogammaglobulinemia 0 trials Sub-types →
Activated PI3K-delta syndrome 5 trials · 6 incl. sub-types
2 sub-types
- Immunodeficiency 14 6 trials
- Immunodeficiency 36 with lymphoproliferation 0 trials
Isolated agammaglobulinemia 0 trials · 4 incl. sub-types
2 sub-types
- Bruton-type agammaglobulinemia 4 trials
- Autosomal agammaglobulinemia 1 trial Sub-types →
Good syndrome 0 trials
Agammaglobulinemia 10, autosomal dominant 0 trials
Agammaglobulinemia 8b, autosomal recessive 0 trials
Agammaglobulinemia 9, autosomal recessive 0 trials
Agammaglobulinemia, autosomal recessive, due to BOB1 deficiency 0 trials
Congenital agammaglobulinemia 0 trials
2 sub-types
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome 0 trials
- Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia 0 trials
Immunodeficiency 61 0 trials

Most studied deeper sub-types

Immunodeficiency, common variable, 12 (1) Pancytopenia due to IKZF1 mutations (1) Agammaglobulinemia 2, autosomal recessive (0) Agammaglobulinemia 3, autosomal recessive (0) Agammaglobulinemia 4, autosomal recessive (0) Agammaglobulinemia 5, autosomal dominant (0) Agammaglobulinemia 6, autosomal recessive (0) Agammaglobulinemia 7, autosomal recessive (0) Agammaglobulinemia 8, autosomal dominant (0) Autosomal recessive agammaglobulinemia 1 (0) Combined immunodeficiency due to LRBA deficiency (0) Deficiency in anterior pituitary function - variable immunodeficiency syndrome (0) IL21-related infantile inflammatory bowel disease (0) Immune deficiency, familial variable (0) Immunodeficiency, common variable, 1 (0) Immunodeficiency, common variable, 10 (0) Immunodeficiency, common variable, 14 (0) Immunodeficiency, common variable, 15 (0) Immunodeficiency, common variable, 2 (0) Immunodeficiency, common variable, 3 (0)

Including sub-types (85) Tagged with Agammaglobulinemia (16)

Trials to join now! 41 Not yet recruiting 7 Not yet finished but already full! 15 Completed 21 Terminated 1

Experimental drug shows promise for rare immune disorder, but study cut short

Disease control Stopped early

This study tested the long-term safety and effectiveness of a drug called CDZ173 in people with APDS/PASLI, a rare genetic condition that causes a weak immune system and swollen lymph nodes. The 37 participants had already taken CDZ173 or a similar drug in a previous study. The t…

Phase 2/3 • Sponsor: Pharming Technologies B.V. • Aim: Disease control

Last updated Jun 27, 2026 12:01 UTC

Agammaglobulinemia

Where it sits in the disease tree

Most studied deeper sub-types

Experimental drug shows promise for rare immune disorder, but study cut short