Adult glioblastoma

This early-stage trial is testing an experimental drug called belzutifan in people with advanced solid tumors that have not responded to standard treatments. Belzutifan works by blocking a protein (HIF-2α) that tumors use to survive in low-oxygen conditions. The main goal is to f…

This early-phase trial tests a new targeted drug called MLN0128 combined with bevacizumab (Avastin) in about 50 patients whose glioblastoma or other solid tumors have returned or not responded to standard treatment. The main goal is to find the safest dose and see how the body ha…

This early-stage study tested the safety and best dose of vorinostat when given with the chemotherapy drug temozolomide in 83 adults with aggressive brain tumors called malignant gliomas. The goal was to see if adding vorinostat could make the tumor cells more sensitive to chemot…

This study tests whether a personalized, two-phase radiation therapy approach can better control glioblastoma, an aggressive brain cancer. The treatment adapts the radiation plan based on tumor changes during therapy, potentially targeting the tumor more precisely while sparing h…

This phase 2 trial tests a higher radiation dose given over just 3 weeks for patients 65 and older with glioblastoma or grade 4 astrocytoma. Using a special MRI-guided machine (MR-Linac), doctors can adjust the radiation daily to target the tumor more precisely. The goal is to se…

This Phase 2 trial tests an experimental chemotherapy drug called berubicin against a standard drug (lomustine) in 252 adults with recurrent glioblastoma, a severe brain cancer. The goal is to see if berubicin can help patients live longer after standard first-line treatment has …