Adrenoleukodystrophy
MONDO:0018544A peroxisomal disorder resulting in cerebral demyelination, axonal dysfunction in the spinal cord leading to spastic paraplegia, adrenal insufficiency and in some cases testicular insufficiency.
Also known as: ABCD1 deficiency, ALD, Bronze-Schilder disease, Siemerling-Creutzfeldt disease, X-ALD, X-Linked Adrenoleukodystrophy, X-linked ALD, X-linked adrenoleukodystrophy
23 clinical trials for this condition and its sub-types, 19 tagged with Adrenoleukodystrophy itself.
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Sub-types of Adrenoleukodystrophy
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Adrenomyeloneuropathy 7 trials
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Isolated adrenal insufficiency 0 trials
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Experimental gene therapy aims to halt fatal brain disease in children
Disease control Not yet recruitingThis trial tests a gene therapy for X-linked adrenoleukodystrophy (X-ALD), a rare genetic disease that damages the brain. The therapy uses a modified virus to deliver a working copy of the faulty gene directly into the spinal fluid and bloodstream. Up to 30 patients aged 1 year a…
Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Could pomegranate supplements help heal the gut in Alcohol-Related liver disease?
Knowledge-focused Not yet recruitingThis study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…
Sponsor: University of Louisville • Aim: Knowledge-focused
Last updated Jul 26, 2026 00:00 UTC
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Tiny trial to see if a dye helps adrenal surgery
Knowledge-focused Not yet recruitingThis study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…
Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC