Adrenocortical insufficiency
MONDO:0000004An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).
Also known as: adrenal cortical hypofunction, adrenal cortical insufficiency, adrenal gland insufficiency, adrenal insufficiency, adrenocortical insufficiency, hypocortisolemia, hypocortisolism, hypoadrenalism
78 clinical trials for this condition and its sub-types, 33 tagged with Adrenocortical insufficiency itself.
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Sub-types of Adrenocortical insufficiency
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Primary adrenal insufficiency 5 trials · 48 incl. sub-types
2 sub-types
- Chronic primary adrenal insufficiency 6 trials · 47 incl. sub-types Sub-types →
- Acute adrenal insufficiency 0 trials Sub-types →
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Secondary adrenal insufficiency 3 trials
Most studied deeper sub-types
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Halted gene therapy study raises questions for AMN patients
Disease control Stopped earlyThis early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…
Phase 1/2 • Sponsor: SwanBio Therapeutics, Inc. • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Rare disease mystery: scientists watch AMN progress in hopes of finding a cure
Knowledge-focused Stopped earlyThis study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…
Sponsor: SwanBio Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC