Adrenocortical insufficiency
MONDO:0000004An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).
Also known as: adrenal cortical hypofunction, adrenal cortical insufficiency, adrenal gland insufficiency, adrenal insufficiency, adrenocortical insufficiency, hypocortisolemia, hypocortisolism, hypoadrenalism
78 clinical trials for this condition and its sub-types, 33 tagged with Adrenocortical insufficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Adrenocortical insufficiency
-
Primary adrenal insufficiency 5 trials · 48 incl. sub-types
2 sub-types
- Chronic primary adrenal insufficiency 6 trials · 47 incl. sub-types Sub-types →
- Acute adrenal insufficiency 0 trials Sub-types →
-
Secondary adrenal insufficiency 3 trials
Most studied deeper sub-types
-
Could a Once-Daily pill replace Twice-Daily dosing for adrenal gland recovery?
Disease control Not yet recruitingThis study compares two steroid replacement therapies—methylprednisolone and hydrocortisone—in people whose adrenal glands have stopped working properly due to long-term use of high-dose steroids. The goal is to see whether a single morning dose of methylprednisolone is as good a…
Phase 4 • Sponsor: University Medical Centre Ljubljana • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
-
Steroid tapering showdown: which method wins for RA patients?
Disease control Not yet recruitingThis study compares two strategies for slowly reducing prednisolone (a steroid) in people with stable rheumatoid arthritis. One method splits a 5 mg tablet into halves, the other reduces by 1 mg at a time. Over six months, 206 participants will be followed to see which approach k…
Phase 4 • Sponsor: Seoul National University Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
-
Could a simple saliva test replace blood draws for hormone monitoring?
Knowledge-focused Not yet recruitingThis study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuation…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC