Adenomyosis

This trial tests whether MRI-guided High-Intensity Focused Ultrasound (HIFU) can ease symptoms of adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers plan to enroll 20 women aged 18 and older who have adenomyosis …

This trial asks whether routinely identifying and protecting the ureters (the tubes that carry urine) during a laparoscopic hysterectomy for non-cancerous conditions is better than doing so only when needed. It compares operative time and safety between the two approaches in wome…

This study tests whether taking linzagolix (Yselty) for 3 to 6 months before an embryo transfer can improve live birth rates in women with adenomyosis who have experienced repeated implantation failure. Adenomyosis can make the womb lining less receptive to embryos, even when the…

This study tests whether adding letrozole to standard GnRH agonist therapy improves pregnancy rates in women with adenomyosis undergoing frozen embryo transfer. About 700 participants will be randomly assigned to one of two groups. The main goal is to see if more women have a hea…

This study tests whether adding nintedanib, a drug that reduces scarring, to standard progesterone therapy can improve live birth rates in infertile women with adenomyosis. About 328 women aged 20-38 with frozen embryos will take either nintedanib plus progesterone or progesteron…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study compares two advanced, minimally invasive hysterectomy techniques—TU-LESS (through the belly button) and vNOTES (through the vagina)—in 210 women with an enlarged uterus. The goal is to see which method leads to faster recovery, less pain, and shorter hospital stays. P…

This study compares total laparoscopic hysterectomy (removing the whole uterus including the cervix) with subtotal laparoscopic hysterectomy (keeping the cervix) in 500 women with benign conditions like fibroids or endometriosis. The main goal is to see which surgery leads to bet…

This study is a large registry that will collect detailed information from thousands of women undergoing surgery for non-cancerous gynecologic conditions like fibroids, endometriosis, and ovarian cysts. The goal is to track surgical techniques, complications, and recovery in real…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…