Acute liver failure
MONDO:0019542Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.
Also known as: acute hepatic failure, fulminant hepatic failure
25 clinical trials for this condition and its sub-types, 16 tagged with Acute liver failure itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Acute liver failure
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Artificial liver device tested in humans for first time
Disease control CompletedThis early-stage trial tested a device called miroliverELAP, which uses a bioengineered liver graft to filter blood outside the body, in 10 adults with acute liver failure. The goal was to check safety and see if it can support the liver for up to 48 hours, giving time for recove…
Phase 1 • Sponsor: Miromatrix Medical Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Cheaper liver dialysis machine could be just as effective
Disease control CompletedThis study compares two machines that clean the blood of toxins when the liver fails: MARS (a standard system) and SPAD (a simpler, cheaper alternative). Thirty-four patients with severe liver failure will try both machines in random order. The goal is to see if SPAD works as wel…
Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 26, 2026 16:41 UTC
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Liver failure treatment MARS: does it help avoid transplants?
Knowledge-focused CompletedThis study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC