Acute leukemia

MONDO:0010643

A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).

Also known as: acute leukaemia (disease), acute leukemia, acute leukemia (disease), leukemia, acute, X-linked, stem cell leukaemia, stem cell leukaemia (disease), stem cell leukemia, stem cell leukemia (disease)

4044 clinical trials for this condition and its sub-types, 124 tagged with Acute leukemia itself.

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Where it sits in the disease tree

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Part of

↑ Acute disease (4756) ↑ Leukemia (2566)

Sub-types of Acute leukemia

Acute lymphoblastic leukemia 508 trials · 1,319 incl. sub-types
12 sub-types
- B-cell chronic lymphocytic leukemia 509 trials · 538 incl. sub-types Sub-types →
- B-cell acute lymphoblastic leukemia 245 trials · 259 incl. sub-types Sub-types →
- Childhood acute lymphoblastic leukemia 96 trials · 136 incl. sub-types Sub-types →
- Precursor B-cell acute lymphoblastic leukemia 68 trials · 113 incl. sub-types Sub-types →
- T-cell acute lymphoblastic leukemia 75 trials · 104 incl. sub-types Sub-types →
- Acute biphenotypic leukemia 88 trials · 91 incl. sub-types Sub-types →
- Adult acute lymphoblastic leukemia 43 trials · 54 incl. sub-types Sub-types →
- Prolymphocytic leukemia 20 trials · 38 incl. sub-types Sub-types →
- Plasma cell leukemia 32 trials
- Lymphoblastic leukemia, acute, with lymphomatous features 7 trials
- Precursor T-cell acute lymphoblastic leukemia 4 trials
- Null-cell leukemia 0 trials
Acute myeloid leukemia 1,098 trials · 1,194 incl. sub-types
78 sub-types
- Acute leukemia of ambiguous lineage 53 trials · 145 incl. sub-types Sub-types →
- Therapy related acute myeloid leukemia and myelodysplastic syndrome 87 trials · 88 incl. sub-types Sub-types →
- Acute myeloid leukemia by FAB classification 0 trials · 60 incl. sub-types Sub-types →
- Acute myeloid leukemia with multilineage dysplasia 34 trials
- Acute myeloid leukemia with mutated NPM1 25 trials
- Inherited acute myeloid leukemia 1 trial · 25 incl. sub-types Sub-types →
- Childhood acute myeloid leukemia 24 trials
- Acute myeloid leukemia, MLL gene rearrangement 23 trials
- Acute monocytic leukemia 20 trials Sub-types →
- Acute myeloid leukemia, FLT3 internal tandem duplication 18 trials
- Acute myeloid leukemia with 11q23 abnormalities 11 trials
- Acute myeloid leukemia, inv(16)(p13.1;q22) 10 trials
- Acute myeloid leukemia, t(16;16)(p13.1;q22) 10 trials
- Acute myeloid leukemia with BCR-ABL1 7 trials
- Acute myeloid leukemia with t(8;21)(q22;q22) translocation 7 trials
- Acute myeloid leukemia, del(5q31-q32) 5 trials
- Acute myeloid leukemia, t(8;21)(q22; q22.1) 5 trials
- Core binding factor acute myeloid leukemia 5 trials
- Acute myeloid leukemia with CEBPA somatic mutations 1 trial
- Acute myeloid leukemia with t(6;9)(p23;q34) 1 trial
- Acute myeloid leukemia, FLT3 tyrosine kinase domain point mutation 1 trial
- Acute myeloid leukemia, biallelic CEBPA gene mutation 1 trial
- Acute myeloid leukemia, t(15;17)(q24;q21) 1 trial
- Acute myeloid leukemia, t(v;11q23.3) 1 trial
- Acute myeloid leukemia with CBFA2T3-GLIS2 fusion 0 trials
- Acute myeloid leukemia with FUS-ERG fusion 0 trials
- Acute myeloid leukemia with MNX1-ETV6 fusion 0 trials
- Acute myeloid leukemia with NPM1 somatic mutations 0 trials
- Acute myeloid leukemia with NPM1-MLF1 fusion 0 trials
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 0 trials
- Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) 0 trials
- Acute myeloid leukemia with t(8;16)(p11;p13) translocation 0 trials
- Acute myeloid leukemia with t(9;11)(p22;q23) 0 trials
- Acute myeloid leukemia, CEBPA gene mutation 0 trials
- Acute myeloid leukemia, GATA1 gene mutation 0 trials
- Acute myeloid leukemia, KIT exon 17 mutation 0 trials
- Acute myeloid leukemia, KIT exon 8 mutation 0 trials
- Acute myeloid leukemia, KIT gene mutation 0 trials
- Acute myeloid leukemia, KRAS gene mutation 0 trials
- Acute myeloid leukemia, Monosomy 5 0 trials
- Acute myeloid leukemia, Monosomy 7 0 trials
- Acute myeloid leukemia, NRAS gene mutation 0 trials
- Acute myeloid leukemia, Non-KMT2A MLLT10 rearrangement positive 0 trials
- Acute myeloid leukemia, PTPN11 gene mutation 0 trials
- Acute myeloid leukemia, RUNX1 gene mutation 0 trials
- Acute myeloid leukemia, Trisomy 8 0 trials
- Acute myeloid leukemia, WT1 gene mutation 0 trials
- Acute myeloid leukemia, del(13q14-q21) 0 trials
- Acute myeloid leukemia, der12p 0 trials
- Acute myeloid leukemia, inv(16)(p13.3;q24.3) 0 trials
- Acute myeloid leukemia, inv(3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, loss of chromosome 17p 0 trials
- Acute myeloid leukemia, monoallelic CEBPA gene mutation 0 trials
- Acute myeloid leukemia, t(10;11)(p11.2;q23) 0 trials
- Acute myeloid leukemia, t(10;11)(p12;q23) 0 trials
- Acute myeloid leukemia, t(11;15)(p15;q35) 0 trials
- Acute myeloid leukemia, t(11;17) 0 trials
- Acute myeloid leukemia, t(11;19)(q23.3;p13.3) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13.1) 0 trials
- Acute myeloid leukemia, t(16;21)(p11;q22) 0 trials
- Acute myeloid leukemia, t(16;21)(q24;q22) 0 trials
- Acute myeloid leukemia, t(1;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(1;22) 0 trials
- Acute myeloid leukemia, t(1;22)(p13;q13) 0 trials
- Acute myeloid leukemia, t(2;12) 0 trials
- Acute myeloid leukemia, t(3;12)(q23;p12.3) 0 trials
- Acute myeloid leukemia, t(3;3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, t(3;5)(q25;q34) 0 trials
- Acute myeloid leukemia, t(4;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(5;11)(q35;p15) 0 trials
- Acute myeloid leukemia, t(6;11)(q27;q23) 0 trials
- Acute myeloid leukemia, t(6;9)(p23;q34.1) 0 trials
- Acute myeloid leukemia, t(7;12)(q36;p13) 0 trials
- Acute myeloid leukemia, t(8;16) 0 trials
- Acute myeloid leukemia, t(9;11)(p21.3;q23.3) 0 trials
- Acute myeloid leukemia, t(9;22)(q34.1;q11.2) 0 trials
- Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) 0 trials
Leukemia, acute, X-linked 0 trials
Subacute leukemia 0 trials

Most studied deeper sub-types

Chronic lymphocytic leukemia/small lymphocytic lymphoma (108) Mixed phenotype acute leukemia (79) Hairy cell leukemia (40) B-cell childhood acute lymphoblastic leukemia (37) Myeloid sarcoma (28) Acute undifferentiated leukemia (27) Acute myeloblastic leukemia with maturation (26) Acute promyelocytic leukemia (20) T-cell prolymphocytic leukemia (17) B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (13) B-cell adult acute lymphocytic leukemia (12) Aggressive NK-cell leukemia (11) T-cell childhood acute lymphocytic leukemia (10) Hairy cell leukemia variant (9) Refractory hairy cell leukemia (9) B-cell prolymphocytic leukemia (7) Bilineal acute myeloid leukemia (6) Acute erythroid leukemia (5) Acute megakaryoblastic leukemia (5) Myeloid leukemia associated with down syndrome (5)

Including sub-types (4044) Tagged with Acute leukemia (124)

Trials to join now! 59 Not yet recruiting 14 Not yet finished but already full! 25 Completed 25 Terminated 1

New cell therapy aims to stop transplant complications in blood cancer patients

Disease control Stopped early

This early-phase study tested whether a special type of cell (interferon gamma-primed mesenchymal stromal cells) could be safely given to prevent graft-versus-host disease, a common and serious complication after bone marrow transplant. Only 4 patients with acute leukemia or myel…

Phase 1 • Sponsor: Edwin Horwitz • Aim: Disease control

Last updated Jun 27, 2026 09:04 UTC

Acute leukemia

Where it sits in the disease tree

Most studied deeper sub-types

New cell therapy aims to stop transplant complications in blood cancer patients