Achalasia
MONDO:0008698A finding indicating the lack of adequate relaxation of the lower esophageal sphincter resulting in difficulty swallowing food.
Also known as: achalasia, achalasia (disease), achalasia of cardia, achalasia of oesophagus, cardiospasm, esophageal achalasia
48 clinical trials for this condition and its sub-types, 35 tagged with Achalasia itself.
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Sub-types of Achalasia
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Idiopathic achalasia 12 trials
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Achalasia, familial esophageal 0 trials
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Can a diet and lifestyle program replace acid reflux pills after achalasia surgery?
Disease control OngoingThis study tests whether a structured program of dietary changes, lifestyle adjustments, and nutrient correction can reduce reflux symptoms in patients who had POEM surgery for achalasia. Many patients develop GERD after POEM and rely on long-term acid-reducing medications. The t…
Sponsor: Asian Institute of Gastroenterology, India • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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No-Scalpel fix for swallowing disorder tracked in massive study
Disease control By invitation onlyThis study is tracking 5,000 adults with achalasia, a condition where the esophagus fails to relax and push food into the stomach. All participants are treated with POEM, a procedure that uses an endoscope to cut the tight muscle without any incisions on the body. Researchers wil…
Sponsor: Indiana University • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Painkiller-Sparing nerve block trial pulled before it began
Symptom relief CancelledThis study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…
Phase 2/3 • Sponsor: Baylor Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Anesthetics' hidden impact on swallowing muscles revealed
Knowledge-focused By invitation onlyThis study looks at how common anesthetics change the way the esophagus moves during a special imaging procedure called FLIP. Researchers will measure muscle flexibility and contraction in 30 adults with swallowing problems like achalasia. The goal is to better understand how ane…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Researchers track recovery after keyhole surgery for swallowing disorders
Knowledge-focused OngoingThis study follows 200 patients who had minimally invasive surgery for conditions like achalasia, GERD, or hiatal hernia. Each year, patients fill out questionnaires about their symptoms and quality of life, and doctors review their medical records. The goal is to understand how …
Sponsor: Ottawa Hospital Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Tiny tools, big promise: endoscopic procedures take on major GI surgery
Knowledge-focused By invitation onlyThis study tracks 500 adults with conditions like acid reflux, achalasia, or complications after weight-loss surgery. Participants choose either a newer endoscopic procedure (done through a scope) or standard surgery. Researchers will compare how well each approach controls sympt…
Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC