New pill shows promise for tough lung cancer mutation

NCT ID NCT05967689

Recruiting now Disease control Sponsor: Taiho Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2b trial tests an oral drug called zipalertinib in 220 people with advanced non-small cell lung cancer that has certain EGFR mutations. The goal is to see if the drug can shrink tumors and how safe it is. Participants take the drug daily, and researchers will monitor their response and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

zipalertinib (oral tablet)

What this could lead to

If successful, this could provide a new targeted treatment option for people with a hard-to-treat form of lung cancer.

What could go wrong

This is a mid-stage trial, so the drug may not prove effective or safe enough for approval. Side effects are possible, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

carcinoma lung disorder non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OR METASTATIC NSCLC HARBORING EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) EXON 20 INSERTION (EX20INS) MUTATIONS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Ajou University Hospital
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea
Asan Medical Center
RECRUITING

Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 05505, South Korea
Azienda Ospedaliero - Universitaria Careggi
RECRUITING

Florence, Florence, 50134, Italy
Azienda Ospedaliero-Universitaria di Parma
RECRUITING

Parma, 43126, Italy
Azienda Socio-Sanitaria Territoriale di Cremona
RECRUITING

Cremona, 26100, Italy
Bagcilar Medipol Mega Universite Hastanesi
WITHDRAWN

Istanbul, 34214, Turkey (Türkiye)
Bankstown-Lidcombe Hospital
RECRUITING

Bankstown, New South Wales, 2200, Australia
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CHU Caen Normandie
RECRUITING

Caen, Basse-Normandie, 14033, France
Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
Centre Hospitalier Universitaire Limoges
RECRUITING

Limoges, Limousin, 87042, France
Centre Leon Berard
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France
Chonnam National University Hwasun Hospital
WITHDRAWN

Hwasun-gun, Jeollanam-do, 58128, South Korea
City of Hope - Duarte
RECRUITING

Duarte, California, 91010, United States
Complejo Hospitalario de Jaen
RECRUITING

Jaén, 23007, Spain
Comprehensive Cancer Centers of Nevada - Central Valley - Twain
RECRUITING

Las Vegas, Nevada, 89169, United States
Gabrail Cancer and Research Center
RECRUITING

Canton, Ohio, 44718, United States
Genesis Care North Shore
RECRUITING

Saint Leonards, New South Wales, 2065, Australia
Gesundheit Nordhessen Holding AG
RECRUITING

Kassel, Hassen, 34125, Germany
Gyeongsang National University Hospital
RECRUITING

Jinju, Gyeongsangnamdo [Kyongsangnam-do], 52727, South Korea
Hopital Ambroise Pare
RECRUITING

Boulogne-Billancourt, Île-de-France Region, 92100, France
Hopital Haut Leveque
RECRUITING

Pessac, New Aquitaine, 33604, France
Hopital Nord Laennec
RECRUITING

Saint-Herblain, 44800, France
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Quirónsalud Barcelona
RECRUITING

Barcelona, 08023, Spain
Hospital Regional Universitario de Málaga - Hospital General
RECRUITING

Málaga, Malaga, 29010, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hôpital Nord de Marseille
RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13015, France
IDS Pharmacy
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Inha University Hospital
RECRUITING

Incheon, Incheon Gwang'yeogsi [Inch'on-Kwangyokshi], 22332, South Korea
Institut Curie
RECRUITING

Paris, Île-de-France Region, 75005, France
Istinye Üniversite Hastanesi Liv Hospital Bahcesehir
RECRUITING

Esenyurt, Istanbul, 34517, Turkey (Türkiye)
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Joondalup Hospital Pharmacy
RECRUITING

Joondalup, Western Australia, 6027, Australia
Kindai University Hospital
RECRUITING

Sayama, Osaka, 589-8511, Japan
Korea University Guro Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 08308, South Korea
MD Anderson Cancer Center Madrid
RECRUITING

Madrid, 28033, Spain
MSK Cancer Center
RECRUITING

Long Island City, New York, 11101, United States
Medical Park Seyhan Hastanesi
RECRUITING

Adana, 01140, Turkey (Türkiye)
Memorial Sloan Kettering Cancer Center - Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center - Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center - Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Cancer Center - Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Cancer Center - Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Cancer Center - Westchester
RECRUITING

Harrison, New York, 10604, United States
NHO Kyushu Cancer Center
RECRUITING

Fukuoka, Hukuoka, 811-1395, Japan
National Cancer Center - Korea
WITHDRAWN

Goyang-si, Gyeonggi-do, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Chuo Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 951-8566, Japan
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, England, NG5 1PB, United Kingdom
Nouvel Hôpital Civil
WITHDRAWN

Strasbourg, Aslace, 67091, France
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Ospedale S. Maria delle Croci
RECRUITING

Ravenna, 48121, Italy
Prof. Dr. Suleyman Yalcin Sehir Hastanesi
RECRUITING

Istanbul, 34722, Turkey (Türkiye)
Queen Mary Hospital
RECRUITING

Pok Fu Lam, Hong Kong Island, Hong Kong
Royal Free London NHS Foundation Trust
RECRUITING

London, England, NW3 2QG, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Saint Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Sendai Kousei Hospital
RECRUITING

Sendai, Miyagi, 980-0873, Japan
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03080, South Korea
Seoul St. Mary's Hospital
WITHDRAWN

Soeul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 06591, South Korea
Shizuoka Cancer Center
RECRUITING

Sunto-gun, Shizuoka, 411-8777, Japan
The Christie NHS Foundation Trust
RECRUITING

Manchester, England, M20 4BX, United Kingdom
The Royal Free Hospital NHS Foundation Trust
RECRUITING

Barnet, England, EN5 3DJ, United Kingdom
The Toledo Clinic Cancer Center
WITHDRAWN

Toledo, Ohio, 43623, United States
Trakya Üniversitesi Saglik Arastirma ve Uygulama Merkezi
RECRUITING

Edirne, 22030, Turkey (Türkiye)
UKGM Studienzentrale
RECRUITING

Giessen, 35392, Germany
UKR Innere Med II Pneumologie
WITHDRAWN

Regensburg, 93053, Germany
UOMi Clinica Mi Tres Torres
RECRUITING

Barcelona, 08017, Spain
Uniklinik Dresden
RECRUITING

Dresden, 01307, Germany
University of Alabama at Birmingham
WITHDRAWN

Birmingham, Alabama, 35294, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
William Osler Health System - Brampton Civic Hospital
RECRUITING

Brampton, L6R 3J7, Canada
Zangmeister Cancer Center
WITHDRAWN

Columbus, Ohio, 43219, United States